Molecular determinants of peri-apical targeting of inositol 1,4,5-trisphosphate receptor type 3 in cholangiocytes

• 主要作者: Rodrigues M.A.
• 其他作者: Mahidol University
• 格式: Review
• 出版: 2023
• 主題: Medicine
• 在線閱讀: https://repository.li.mahidol.ac.th/handle/123456789/87237

Fluid and bicarbonate secretion is a principal function of cholangiocytes, and impaired secretion results in cholestasis. Cholangiocyte secretion depends on peri-apical expression of the type 3 inositol trisphosphate receptor (ITPR3), and loss of this intracellular Ca2+ release channel is a final co...