The Effect of Simethicone on the Length of Hospital Stay of Patients Undergoing Laparotomy for Benign Gynecological Procedures with an Enhanced Recovery after Surgery Protocol: A randomized controlled trial

Objectives: To evaluate the efficacy of simethicone in treating postoperative ileus symptoms assessed by length of hospital stay, for patients undergoing elective laparotomy for benign gynecological procedures in the setting of an enhanced recovery after surgery (ERAS) protocol and to identify facto...

Full description

Saved in:
Bibliographic Details
Main Author: Taemamu K.
Other Authors: Mahidol University
Format: Article
Published: 2023
Subjects:
Online Access:https://repository.li.mahidol.ac.th/handle/123456789/87246
Tags: Add Tag
No Tags, Be the first to tag this record!
Institution: Mahidol University
id th-mahidol.87246
record_format dspace
spelling th-mahidol.872462023-06-20T12:26:07Z The Effect of Simethicone on the Length of Hospital Stay of Patients Undergoing Laparotomy for Benign Gynecological Procedures with an Enhanced Recovery after Surgery Protocol: A randomized controlled trial Taemamu K. Mahidol University Medicine Objectives: To evaluate the efficacy of simethicone in treating postoperative ileus symptoms assessed by length of hospital stay, for patients undergoing elective laparotomy for benign gynecological procedures in the setting of an enhanced recovery after surgery (ERAS) protocol and to identify factors associated with a decreased length of hospital stay. Materials and Methods: A single-center randomized controlled trial (TCTR20210204012) was conducted at the Department of Obstetrics and Gynecology, Faculty of Medicine Siriraj Hospital, Mahidol University, Thailand, between February and June 2021. In all, 182 patients were randomized into 2 groups: an "immediate-simethicone-administration-group" (administered 160 mg of simethicone immediately after surgery; n = 91) and a "non-immediate-simethicone-administration-group" (no immediate simethicone used; n = 91). The lengths of stay and other hospital data were analyzed. Results: No significant difference was observed in the lengths of stay of the immediate-simethicone-administration and non-immediate-simethicone-administration groups (p = 0.132), nor in their incidences of postoperative nausea/vomiting, abdominal discomfort, and diarrhea. A multivariate analysis found that the significant predictor of a decreased length of hospital stay was an estimated blood loss of < 500 mL (odds ratio 5.82, 95% confidence interval 1.20, 28.16, p = 0.029). Conclusion: Immediately chewing simethicone after surgery had no effect on the length of hospital stay in cases of benign laparotomy for gynecological procedures in the setting of an ERAS protocol. An estimated blood loss below 500 mL was a predictor of early hospital discharge. 2023-06-20T05:26:07Z 2023-06-20T05:26:07Z 2022-09-01 Article Thai Journal of Obstetrics and Gynaecology Vol.30 No.5 (2022) , 329-342 10.14456/tjog.2022.39 26730871 08576084 2-s2.0-85139235898 https://repository.li.mahidol.ac.th/handle/123456789/87246 SCOPUS
institution Mahidol University
building Mahidol University Library
continent Asia
country Thailand
Thailand
content_provider Mahidol University Library
collection Mahidol University Institutional Repository
topic Medicine
spellingShingle Medicine
Taemamu K.
The Effect of Simethicone on the Length of Hospital Stay of Patients Undergoing Laparotomy for Benign Gynecological Procedures with an Enhanced Recovery after Surgery Protocol: A randomized controlled trial
description Objectives: To evaluate the efficacy of simethicone in treating postoperative ileus symptoms assessed by length of hospital stay, for patients undergoing elective laparotomy for benign gynecological procedures in the setting of an enhanced recovery after surgery (ERAS) protocol and to identify factors associated with a decreased length of hospital stay. Materials and Methods: A single-center randomized controlled trial (TCTR20210204012) was conducted at the Department of Obstetrics and Gynecology, Faculty of Medicine Siriraj Hospital, Mahidol University, Thailand, between February and June 2021. In all, 182 patients were randomized into 2 groups: an "immediate-simethicone-administration-group" (administered 160 mg of simethicone immediately after surgery; n = 91) and a "non-immediate-simethicone-administration-group" (no immediate simethicone used; n = 91). The lengths of stay and other hospital data were analyzed. Results: No significant difference was observed in the lengths of stay of the immediate-simethicone-administration and non-immediate-simethicone-administration groups (p = 0.132), nor in their incidences of postoperative nausea/vomiting, abdominal discomfort, and diarrhea. A multivariate analysis found that the significant predictor of a decreased length of hospital stay was an estimated blood loss of < 500 mL (odds ratio 5.82, 95% confidence interval 1.20, 28.16, p = 0.029). Conclusion: Immediately chewing simethicone after surgery had no effect on the length of hospital stay in cases of benign laparotomy for gynecological procedures in the setting of an ERAS protocol. An estimated blood loss below 500 mL was a predictor of early hospital discharge.
author2 Mahidol University
author_facet Mahidol University
Taemamu K.
format Article
author Taemamu K.
author_sort Taemamu K.
title The Effect of Simethicone on the Length of Hospital Stay of Patients Undergoing Laparotomy for Benign Gynecological Procedures with an Enhanced Recovery after Surgery Protocol: A randomized controlled trial
title_short The Effect of Simethicone on the Length of Hospital Stay of Patients Undergoing Laparotomy for Benign Gynecological Procedures with an Enhanced Recovery after Surgery Protocol: A randomized controlled trial
title_full The Effect of Simethicone on the Length of Hospital Stay of Patients Undergoing Laparotomy for Benign Gynecological Procedures with an Enhanced Recovery after Surgery Protocol: A randomized controlled trial
title_fullStr The Effect of Simethicone on the Length of Hospital Stay of Patients Undergoing Laparotomy for Benign Gynecological Procedures with an Enhanced Recovery after Surgery Protocol: A randomized controlled trial
title_full_unstemmed The Effect of Simethicone on the Length of Hospital Stay of Patients Undergoing Laparotomy for Benign Gynecological Procedures with an Enhanced Recovery after Surgery Protocol: A randomized controlled trial
title_sort effect of simethicone on the length of hospital stay of patients undergoing laparotomy for benign gynecological procedures with an enhanced recovery after surgery protocol: a randomized controlled trial
publishDate 2023
url https://repository.li.mahidol.ac.th/handle/123456789/87246
_version_ 1781414943346655232