The Association of pre-miR27a Gene Polymorphism and Clinicopathological Data in Thai Breast Cancer Patients
BACKGROUND: MiR27a plays an important role in carcinogenesis, cell proliferation, apoptosis, invasion, migration and angiogenesis. Several studies have identified an important role of pre-miR27a (rs895819) A>G polymorphism in several types of cancer. This research aims to investigate the associat...
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th-mahidol.879512023-07-20T01:00:56Z The Association of pre-miR27a Gene Polymorphism and Clinicopathological Data in Thai Breast Cancer Patients Sanguansin S. Mahidol University Biochemistry, Genetics and Molecular Biology BACKGROUND: MiR27a plays an important role in carcinogenesis, cell proliferation, apoptosis, invasion, migration and angiogenesis. Several studies have identified an important role of pre-miR27a (rs895819) A>G polymorphism in several types of cancer. This research aims to investigate the association of pre-miR27a (rs895819) A>G and breast cancer susceptibility, clinicopathological data and survival. Blood DNA samples of 143 Thai breast cancer patients and 100 healthy Thai women were studied for pre-miR27a (rs895819) A>G polymorphism using polymerase chain reaction-restriction fragment-length polymorphism (PCR-RFLP). RESULTS: The results revealed that the frequency of pre-miR27a (rs895819) A>G genotypes was not statistically significant different between breast cancer patient and normal control subjects. The rs895819 A>G genotype was significantly associated with clinicopathological parameter of grade III differentiation (P = 0.006), progesterone receptor (P = 0.011) and triple negative (P = 0.031) in breast cancer patients, but not with breast cancer susceptibility. CONCLUSION: The pre-miR27a (rs895819) A>G genotype was significantly associated with poorly differentiated, progesterone receptor and triple-negative in breast cancer patients. Therefore, pre-miR27a (rs895819) A>G may be used as a biomarker for poor prognosis. 2023-07-19T18:00:56Z 2023-07-19T18:00:56Z 2023-06-01 Article Asian Pacific journal of cancer prevention : APJCP Vol.24 No.6 (2023) , 2055-2059 10.31557/APJCP.2023.24.6.2055 2476762X 37378936 2-s2.0-85163617666 https://repository.li.mahidol.ac.th/handle/123456789/87951 SCOPUS |
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Biochemistry, Genetics and Molecular Biology Sanguansin S. The Association of pre-miR27a Gene Polymorphism and Clinicopathological Data in Thai Breast Cancer Patients |
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BACKGROUND: MiR27a plays an important role in carcinogenesis, cell proliferation, apoptosis, invasion, migration and angiogenesis. Several studies have identified an important role of pre-miR27a (rs895819) A>G polymorphism in several types of cancer. This research aims to investigate the association of pre-miR27a (rs895819) A>G and breast cancer susceptibility, clinicopathological data and survival. Blood DNA samples of 143 Thai breast cancer patients and 100 healthy Thai women were studied for pre-miR27a (rs895819) A>G polymorphism using polymerase chain reaction-restriction fragment-length polymorphism (PCR-RFLP). RESULTS: The results revealed that the frequency of pre-miR27a (rs895819) A>G genotypes was not statistically significant different between breast cancer patient and normal control subjects. The rs895819 A>G genotype was significantly associated with clinicopathological parameter of grade III differentiation (P = 0.006), progesterone receptor (P = 0.011) and triple negative (P = 0.031) in breast cancer patients, but not with breast cancer susceptibility. CONCLUSION: The pre-miR27a (rs895819) A>G genotype was significantly associated with poorly differentiated, progesterone receptor and triple-negative in breast cancer patients. Therefore, pre-miR27a (rs895819) A>G may be used as a biomarker for poor prognosis. |
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Mahidol University |
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Mahidol University Sanguansin S. |
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Sanguansin S. |
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Sanguansin S. |
title |
The Association of pre-miR27a Gene Polymorphism and Clinicopathological Data in Thai Breast Cancer Patients |
title_short |
The Association of pre-miR27a Gene Polymorphism and Clinicopathological Data in Thai Breast Cancer Patients |
title_full |
The Association of pre-miR27a Gene Polymorphism and Clinicopathological Data in Thai Breast Cancer Patients |
title_fullStr |
The Association of pre-miR27a Gene Polymorphism and Clinicopathological Data in Thai Breast Cancer Patients |
title_full_unstemmed |
The Association of pre-miR27a Gene Polymorphism and Clinicopathological Data in Thai Breast Cancer Patients |
title_sort |
association of pre-mir27a gene polymorphism and clinicopathological data in thai breast cancer patients |
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2023 |
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https://repository.li.mahidol.ac.th/handle/123456789/87951 |
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