Poly(ϵ-Caprolactone) Nanospheres Coated on Dental Implants by Integrated Layer-by-Layer Coating Technique

Dental implant infections are a leading cause of implant failure, causing inflammation and bone loss. To combat such infections, a potential solution is the application of a nano-coating technique that utilizes nanotechnology and a drug delivery system to coat the implant surface. This study aimed t...

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Main Author: Patiyananuwat N.
Other Authors: Mahidol University
Format: Conference or Workshop Item
Published: 2023
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Online Access:https://repository.li.mahidol.ac.th/handle/123456789/90564
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spelling th-mahidol.905642023-10-20T01:01:18Z Poly(ϵ-Caprolactone) Nanospheres Coated on Dental Implants by Integrated Layer-by-Layer Coating Technique Patiyananuwat N. Mahidol University Chemical Engineering Dental implant infections are a leading cause of implant failure, causing inflammation and bone loss. To combat such infections, a potential solution is the application of a nano-coating technique that utilizes nanotechnology and a drug delivery system to coat the implant surface. This study aimed to coat dental implants with poly(ϵ-caprolactone) nanospheres (PCL-NPs) loaded with minocycline (MC), an antibacterial agent, using the Layer-by-Layer (LbL) coating technique involving dipping and spraying. The dental implants were coated for 30, 60, 90, and 120 cycles, respectively. The MC/PCL- NPs achieved drug-loading contents of 0.16 ± 0.03, 3.03 ± 0.99, 5.87 ± 0.69, and 6.48 ± 1.68 mg, respectively. The antibacterial study revealed that the release profile of minocycline from the coated dental implants effectively inhibited bacteria growth for a duration of three days. Keywords: Dental implant, nano-coating, nanospheres, poly(ϵ-caprolactone), minocycline, drug delivery system 2023-10-19T18:01:18Z 2023-10-19T18:01:18Z 2023-01-01 Conference Paper Proceedings of the IEEE Conference on Nanotechnology Vol.2023-July (2023) , 484-489 10.1109/NANO58406.2023.10231250 19449380 19449399 2-s2.0-85173589680 https://repository.li.mahidol.ac.th/handle/123456789/90564 SCOPUS
institution Mahidol University
building Mahidol University Library
continent Asia
country Thailand
Thailand
content_provider Mahidol University Library
collection Mahidol University Institutional Repository
topic Chemical Engineering
spellingShingle Chemical Engineering
Patiyananuwat N.
Poly(ϵ-Caprolactone) Nanospheres Coated on Dental Implants by Integrated Layer-by-Layer Coating Technique
description Dental implant infections are a leading cause of implant failure, causing inflammation and bone loss. To combat such infections, a potential solution is the application of a nano-coating technique that utilizes nanotechnology and a drug delivery system to coat the implant surface. This study aimed to coat dental implants with poly(ϵ-caprolactone) nanospheres (PCL-NPs) loaded with minocycline (MC), an antibacterial agent, using the Layer-by-Layer (LbL) coating technique involving dipping and spraying. The dental implants were coated for 30, 60, 90, and 120 cycles, respectively. The MC/PCL- NPs achieved drug-loading contents of 0.16 ± 0.03, 3.03 ± 0.99, 5.87 ± 0.69, and 6.48 ± 1.68 mg, respectively. The antibacterial study revealed that the release profile of minocycline from the coated dental implants effectively inhibited bacteria growth for a duration of three days. Keywords: Dental implant, nano-coating, nanospheres, poly(ϵ-caprolactone), minocycline, drug delivery system
author2 Mahidol University
author_facet Mahidol University
Patiyananuwat N.
format Conference or Workshop Item
author Patiyananuwat N.
author_sort Patiyananuwat N.
title Poly(ϵ-Caprolactone) Nanospheres Coated on Dental Implants by Integrated Layer-by-Layer Coating Technique
title_short Poly(ϵ-Caprolactone) Nanospheres Coated on Dental Implants by Integrated Layer-by-Layer Coating Technique
title_full Poly(ϵ-Caprolactone) Nanospheres Coated on Dental Implants by Integrated Layer-by-Layer Coating Technique
title_fullStr Poly(ϵ-Caprolactone) Nanospheres Coated on Dental Implants by Integrated Layer-by-Layer Coating Technique
title_full_unstemmed Poly(ϵ-Caprolactone) Nanospheres Coated on Dental Implants by Integrated Layer-by-Layer Coating Technique
title_sort poly(ϵ-caprolactone) nanospheres coated on dental implants by integrated layer-by-layer coating technique
publishDate 2023
url https://repository.li.mahidol.ac.th/handle/123456789/90564
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