The efficacy of edaravone (radicut), a free radical scavenger, for cardiovascular disease.
Edaravone was originally developed as a potent free radical scavenger, and has been widely used to treat acute ischemic stroke in Japan since 2001. Free radicals play an important role in the pathogenesis of a variety of diseases, such as cardiovascular diseases and stroke. Therefore, free radicals...
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th-mahidol.9432023-04-12T15:32:03Z The efficacy of edaravone (radicut), a free radical scavenger, for cardiovascular disease. Kikuchi, Kiyoshi Salunya Tancharoen ศรัณยา ตันเจริญ Takeshige, Nobuyuki Yoshitomi, Munetake Morioka, Motohiro Murai, Yoshinaka Tanaka, Eiichiro Mahidol University. Faculty of Dentistry. Department of Pharmacology Cardiovascular disease Edaravone Free radical scavenger Open Access article Edaravone was originally developed as a potent free radical scavenger, and has been widely used to treat acute ischemic stroke in Japan since 2001. Free radicals play an important role in the pathogenesis of a variety of diseases, such as cardiovascular diseases and stroke. Therefore, free radicals may be targets for therapeutic intervention in these diseases. Edaravone shows protective effects on ischemic insults and inflammation in the heart, vessel, and brain in experimental studies. As well as scavenging free radicals, edaravone has anti-apoptotic, anti-necrotic, and anti-cytokine effects in cardiovascular diseases and stroke. Edaravone has preventive effects on myocardial injury following ischemia and reperfusion in patients with acute myocardial infarction. Edaravone may represent a new therapeutic intervention for endothelial dysfunction in the setting of atherosclerosis, heart failure, diabetes, or hypertension, because these diseases result from oxidative stress and/or cytokine-induced apoptosis. This review evaluates the potential of edaravone for treatment of cardiovascular disease, and covers clinical and experimental studies conducted between 1984 and 2013. We propose that edaravone, which scavenges free radicals, may offer a novel option for treatment of cardiovascular diseases. However, additional clinical studies are necessary to verify the efficacy of edaravone. 2015-09-29T09:38:03Z 2016-12-08T09:06:41Z 2015-09-29T09:38:03Z 2016-12-08T09:06:41Z 2015-09-22 2013-07 Article Kikuchi K, Tancharoen S, Takeshige N, Yoshitomi M, Morioka M, Murai Y, et al. The efficacy of edaravone (radicut), a free radical scavenger, for cardiovascular disease. Int J Mol Sci. 2013 Jul 4;14(7):13909-30. 10.3390/ijms140713909 1422-0067 (electronic) https://repository.li.mahidol.ac.th/handle/123456789/943 eng Mahidol University PubMed Central application/pdf |
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Cardiovascular disease Edaravone Free radical scavenger Open Access article |
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Cardiovascular disease Edaravone Free radical scavenger Open Access article Kikuchi, Kiyoshi Salunya Tancharoen ศรัณยา ตันเจริญ Takeshige, Nobuyuki Yoshitomi, Munetake Morioka, Motohiro Murai, Yoshinaka Tanaka, Eiichiro The efficacy of edaravone (radicut), a free radical scavenger, for cardiovascular disease. |
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Edaravone was originally developed as a potent free radical scavenger, and has been widely used to treat acute ischemic stroke in Japan since 2001. Free radicals play an important role in the pathogenesis of a variety of diseases, such as cardiovascular diseases and stroke. Therefore, free radicals may be targets for therapeutic intervention in these diseases. Edaravone shows protective effects on ischemic insults and inflammation in the heart, vessel, and brain in experimental studies. As well as scavenging free radicals, edaravone has anti-apoptotic, anti-necrotic, and anti-cytokine effects in cardiovascular diseases and stroke. Edaravone has preventive effects on myocardial injury following ischemia and reperfusion in patients with acute myocardial infarction. Edaravone may represent a new therapeutic intervention for endothelial dysfunction in the setting of atherosclerosis, heart failure, diabetes, or hypertension, because these diseases result from oxidative stress and/or cytokine-induced apoptosis. This review evaluates the potential of edaravone for treatment of cardiovascular disease, and covers clinical and experimental studies conducted between 1984 and 2013. We propose that edaravone, which scavenges free radicals, may offer a novel option for treatment of cardiovascular diseases. However, additional clinical studies are necessary to verify the efficacy of edaravone. |
author2 |
Mahidol University. Faculty of Dentistry. Department of Pharmacology |
author_facet |
Mahidol University. Faculty of Dentistry. Department of Pharmacology Kikuchi, Kiyoshi Salunya Tancharoen ศรัณยา ตันเจริญ Takeshige, Nobuyuki Yoshitomi, Munetake Morioka, Motohiro Murai, Yoshinaka Tanaka, Eiichiro |
format |
Article |
author |
Kikuchi, Kiyoshi Salunya Tancharoen ศรัณยา ตันเจริญ Takeshige, Nobuyuki Yoshitomi, Munetake Morioka, Motohiro Murai, Yoshinaka Tanaka, Eiichiro |
author_sort |
Kikuchi, Kiyoshi |
title |
The efficacy of edaravone (radicut), a free radical scavenger, for cardiovascular disease. |
title_short |
The efficacy of edaravone (radicut), a free radical scavenger, for cardiovascular disease. |
title_full |
The efficacy of edaravone (radicut), a free radical scavenger, for cardiovascular disease. |
title_fullStr |
The efficacy of edaravone (radicut), a free radical scavenger, for cardiovascular disease. |
title_full_unstemmed |
The efficacy of edaravone (radicut), a free radical scavenger, for cardiovascular disease. |
title_sort |
efficacy of edaravone (radicut), a free radical scavenger, for cardiovascular disease. |
publishDate |
2015 |
url |
https://repository.li.mahidol.ac.th/handle/123456789/943 |
_version_ |
1781415988177141760 |