Enantioselective synthesis of spiro[4.4]non- and spiro[4.5]dec-2-ene-1,6-diones

• Main Authors: B. Chitkul, Y. Pinyopronpanich, C. Thebtaranonth, Y. Thebtaranonth, W. C. Taylor
• Other Authors: Mahidol University
• Format: Article
• Published: 2018
• Subjects: Biochemistry, Genetics and Molecular Biology; Chemistry; Pharmacology, Toxicology and Pharmaceutics
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/9517

Spiro[4.4]non- and spiro[4.5] dec-2-ene-1,6-diones [2; n = 0 and 1] were prepared in moderate to high enantiomeric purities via asymmetric allylation of enamines 6 and ketal derivatives 7 and 8 formed from keto-esters 5, followed by a carbanionic cyclization process. © 1994.