Mutagenic activity of newly synthesized sulfa drugs to Salmonella typhimurium

• Main Authors: Punya Temcharoen, Suwanna Nerapattanakid, Chaivat Toskulkao, Thirayudh Glinsukon, Chitkawee Paovaro, Somsak Ruchirawat
• Other Authors: Mahidol University
• Format: Article
• Published: 2018
• Subjects: Biochemistry, Genetics and Molecular Biology; Pharmacology, Toxicology and Pharmaceutics
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/9522

The mutagenic activity of seven newly synthesized sulfa drugs was studied in Salmonella typhimurium, using forward mutation to 8-azaguanine (8-AG) resistance and reversion mutation assays (Ames test) both in the absence and presence of Aroclor induced rat liver S9. In forward mutation assays, N 1 -m...