Nebulized salbutamol (Asmasal®) in Thai children with asthma: Comparison of three doses
Eleven moderate-to-severe asthmatic children 5-11 years of age who were in stable condition were given (randomly, double-blind) nebulized salbutamol sulfate (Asmasal®) inhalation therapy at doses of 0.1, 0.2 and 0.3 mg/kg body weight on separated days. All three doses of nebulized solution resulted...
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th-mahidol.95682018-02-27T11:27:29Z Nebulized salbutamol (Asmasal®) in Thai children with asthma: Comparison of three doses N. Visitsuntorn V. Wichienwattanachai P. Vichyanond S. Kerdsomnuk M. Tuchinda Mahidol University Immunology and Microbiology Medicine Eleven moderate-to-severe asthmatic children 5-11 years of age who were in stable condition were given (randomly, double-blind) nebulized salbutamol sulfate (Asmasal®) inhalation therapy at doses of 0.1, 0.2 and 0.3 mg/kg body weight on separated days. All three doses of nebulized solution resulted in clinical improvement and improvement of lung function (FEV 1 , FVC, PEFR and FEF(25-75%). A dose of 0.3 mg/kg produced greatest improvement and longest duration of improvement in FEV 1 and PEFR, but the change was statistically significant only in PEFR at 60 minutes (p < 0.05). Five children experienced mild tremors. There were no significant changes in heart rate or blood pressure at any dose. It is concluded that a nebulized solution of salbutamol sulfate at a dose of 0.1-0.3 mg/kg is useful for treatment of asthma in Thai children, with very mild side effects. 2018-02-27T04:26:29Z 2018-02-27T04:26:29Z 1994-10-10 Article Asian Pacific Journal of Allergy and Immunology. Vol.12, No.1 (1994), 7-13 0125877X 2-s2.0-0028143662 https://repository.li.mahidol.ac.th/handle/123456789/9568 Mahidol University SCOPUS https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=0028143662&origin=inward |
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Immunology and Microbiology Medicine N. Visitsuntorn V. Wichienwattanachai P. Vichyanond S. Kerdsomnuk M. Tuchinda Nebulized salbutamol (Asmasal®) in Thai children with asthma: Comparison of three doses |
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Eleven moderate-to-severe asthmatic children 5-11 years of age who were in stable condition were given (randomly, double-blind) nebulized salbutamol sulfate (Asmasal®) inhalation therapy at doses of 0.1, 0.2 and 0.3 mg/kg body weight on separated days. All three doses of nebulized solution resulted in clinical improvement and improvement of lung function (FEV 1 , FVC, PEFR and FEF(25-75%). A dose of 0.3 mg/kg produced greatest improvement and longest duration of improvement in FEV 1 and PEFR, but the change was statistically significant only in PEFR at 60 minutes (p < 0.05). Five children experienced mild tremors. There were no significant changes in heart rate or blood pressure at any dose. It is concluded that a nebulized solution of salbutamol sulfate at a dose of 0.1-0.3 mg/kg is useful for treatment of asthma in Thai children, with very mild side effects. |
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Mahidol University |
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Mahidol University N. Visitsuntorn V. Wichienwattanachai P. Vichyanond S. Kerdsomnuk M. Tuchinda |
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Article |
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N. Visitsuntorn V. Wichienwattanachai P. Vichyanond S. Kerdsomnuk M. Tuchinda |
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N. Visitsuntorn |
title |
Nebulized salbutamol (Asmasal®) in Thai children with asthma: Comparison of three doses |
title_short |
Nebulized salbutamol (Asmasal®) in Thai children with asthma: Comparison of three doses |
title_full |
Nebulized salbutamol (Asmasal®) in Thai children with asthma: Comparison of three doses |
title_fullStr |
Nebulized salbutamol (Asmasal®) in Thai children with asthma: Comparison of three doses |
title_full_unstemmed |
Nebulized salbutamol (Asmasal®) in Thai children with asthma: Comparison of three doses |
title_sort |
nebulized salbutamol (asmasal®) in thai children with asthma: comparison of three doses |
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2018 |
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https://repository.li.mahidol.ac.th/handle/123456789/9568 |
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1763488075842846720 |