Lactic acidosis and hypoglycaemia in children with severe malaria: Pathophysiological and prognostic significance

• Main Authors: S. Krishna, D. W. Wailer, F. Ter Kuile, D. Kwiatkowski, J. Crawley, C. F.C. Craddock, F. Nosten, D. Chapman, D. Brewster, P. A. Holloway, N. J. White
• Other Authors: Mahidol University
• Format: Article
• Published: 2018
• Subjects: Immunology and Microbiology; Medicine
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/9605

Serial clinical and metabolic changes were monitored in 115 Gambian children (1·5–12 years old) with severe malaria. Fifty-three children (46%) had cerebral malaria (coma score < /2) and 21 (18%) died. Admission geometric mean venous blood lactate concentrations were almost twice as high in fata...