An immunohistochemical study of the pathology of fatal malaria: Evidence for widespread endothelial activation and a potential role for intercellular adhesion molecule-1 in cerebral sequestration

• Main Authors: Gareth D.H. Turner, Heather Morrison, Margaret Jones, Timothy M.E. Davis, Sornchai Looareesuwan, Ian D. Buley, Kevin C. Gatter, Christopher I. Newbold, Sasithon Pukritayakamee, Bussarin Nagachinta, Nicholas J. White, Anthony R. Berendt
• Other Authors: John Radcliffe Hospital
• Format: Article
• Published: 2018
• Subjects: Medicine
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/9629
• Institution: Mahidol University

The sequestration of parasitized erythrocytes in the microvasculature of vital organs is central to the pathogenesis of severe Plasmodium falciparum malaria. This process is mediated by specific interactions between parasite adherence ligands and host receptors on vascular endothelium such as interc...