EFFECTIVENESS OF SMS 201-995, A SYNTHETIC, LONG-ACTING SOMATOSTATIN ANALOGUE, IN TREATMENT OF QUININE-INDUCED HYPERINSULINAEMIA

EFFECTIVENESS OF SMS 201-995, A SYNTHETIC, LONG-ACTING SOMATOSTATIN ANALOGUE, IN TREATMENT OF QUININE-INDUCED HYPERINSULINAEMIA

SMS 201-995, a new long-acting, synthetic somatostatin analogue, dose 50 μg/h, given as a continuous intravenous infusion, completely abolished quinine-induced insulin release in 9 healthy Thai volunteers. Hyperinsulinaemia, which caused sustained hypoglycaemia in a 32-year-old post-partum Thai pati...

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Main Authors: R. E. Phillips, S. Looareesuwan, S. R. Bloom, D. A. Warrell, R. C. Turner, D. Quantrill, A. R. Moore
Other Authors: Mahidol University
Format: Article
Published: 2018
Subjects:
Medicine
Online Access:https://repository.li.mahidol.ac.th/handle/123456789/9809
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spelling th-mahidol.98092018-02-27T11:28:59Z EFFECTIVENESS OF SMS 201-995, A SYNTHETIC, LONG-ACTING SOMATOSTATIN ANALOGUE, IN TREATMENT OF QUININE-INDUCED HYPERINSULINAEMIA R. E. Phillips S. Looareesuwan S. R. Bloom D. A. Warrell R. C. Turner D. Quantrill A. R. Moore Mahidol University John Radcliffe Hospital Hammersmith Hospital Medicine SMS 201-995, a new long-acting, synthetic somatostatin analogue, dose 50 μg/h, given as a continuous intravenous infusion, completely abolished quinine-induced insulin release in 9 healthy Thai volunteers. Hyperinsulinaemia, which caused sustained hypoglycaemia in a 32-year-old post-partum Thai patient who was receiving intravenous quinine for falciparum malaria, was suppressed within 30 min of starting SMS 201-995, and the patient became fully conscious. This octapeptide antagonises the stimulatory effect of quinine on the pancreatic beta cell and is a specific therapy for life-threatening hyperinsulinaemic hypoglycaemia complicating falciparum malaria. © 1986. 2018-02-27T04:28:59Z 2018-02-27T04:28:59Z 1986-03-29 Article The Lancet. Vol.327, No.8483 (1986), 713-716 10.1016/S0140-6736(86)91103-7 01406736 2-s2.0-0022593162 https://repository.li.mahidol.ac.th/handle/123456789/9809 Mahidol University SCOPUS https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=0022593162&origin=inward
institution Mahidol University
building Mahidol University Library
continent Asia
country Thailand
Thailand
content_provider Mahidol University Library
collection Mahidol University Institutional Repository
topic Medicine
spellingShingle Medicine
R. E. Phillips
S. Looareesuwan
S. R. Bloom
D. A. Warrell
R. C. Turner
D. Quantrill
A. R. Moore
EFFECTIVENESS OF SMS 201-995, A SYNTHETIC, LONG-ACTING SOMATOSTATIN ANALOGUE, IN TREATMENT OF QUININE-INDUCED HYPERINSULINAEMIA
description SMS 201-995, a new long-acting, synthetic somatostatin analogue, dose 50 μg/h, given as a continuous intravenous infusion, completely abolished quinine-induced insulin release in 9 healthy Thai volunteers. Hyperinsulinaemia, which caused sustained hypoglycaemia in a 32-year-old post-partum Thai patient who was receiving intravenous quinine for falciparum malaria, was suppressed within 30 min of starting SMS 201-995, and the patient became fully conscious. This octapeptide antagonises the stimulatory effect of quinine on the pancreatic beta cell and is a specific therapy for life-threatening hyperinsulinaemic hypoglycaemia complicating falciparum malaria. © 1986.
author2 Mahidol University
author_facet Mahidol University
R. E. Phillips
S. Looareesuwan
S. R. Bloom
D. A. Warrell
R. C. Turner
D. Quantrill
A. R. Moore
format Article
author R. E. Phillips
S. Looareesuwan
S. R. Bloom
D. A. Warrell
R. C. Turner
D. Quantrill
A. R. Moore
author_sort R. E. Phillips
title EFFECTIVENESS OF SMS 201-995, A SYNTHETIC, LONG-ACTING SOMATOSTATIN ANALOGUE, IN TREATMENT OF QUININE-INDUCED HYPERINSULINAEMIA
title_short EFFECTIVENESS OF SMS 201-995, A SYNTHETIC, LONG-ACTING SOMATOSTATIN ANALOGUE, IN TREATMENT OF QUININE-INDUCED HYPERINSULINAEMIA
title_full EFFECTIVENESS OF SMS 201-995, A SYNTHETIC, LONG-ACTING SOMATOSTATIN ANALOGUE, IN TREATMENT OF QUININE-INDUCED HYPERINSULINAEMIA
title_fullStr EFFECTIVENESS OF SMS 201-995, A SYNTHETIC, LONG-ACTING SOMATOSTATIN ANALOGUE, IN TREATMENT OF QUININE-INDUCED HYPERINSULINAEMIA
title_full_unstemmed EFFECTIVENESS OF SMS 201-995, A SYNTHETIC, LONG-ACTING SOMATOSTATIN ANALOGUE, IN TREATMENT OF QUININE-INDUCED HYPERINSULINAEMIA
title_sort effectiveness of sms 201-995, a synthetic, long-acting somatostatin analogue, in treatment of quinine-induced hyperinsulinaemia
publishDate 2018
url https://repository.li.mahidol.ac.th/handle/123456789/9809
_version_ 1763492046432108544

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