Effects of Pyridoxine Deficiency on the Metabolism of N-Nitrosodimethylamine in the Rat

Effects of Pyridoxine Deficiency on the Metabolism of N-Nitrosodimethylamine in the Rat

The alteration in the metabolic activation of N-nitroso-dimethylamine (NDMA) was investigated in the rat during dietary pyridoxine deficiency. The in vitro metabolism of NDMA by demethylase system was measured in both liver and kidney microsomes. The profile of the kidney enzyme appears similar to t...

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Main Authors: A. Aramphongphan, P. Navasumrit, Y. Kuroiwa, T. Yoshida, N. Frank, M. Ruchirawat
Other Authors: Mahidol University
Format: Article
Published: 2018
Subjects:
Medicine
Nursing
Online Access:https://repository.li.mahidol.ac.th/handle/123456789/9830
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spelling th-mahidol.98302018-02-27T11:29:55Z Effects of Pyridoxine Deficiency on the Metabolism of N-Nitrosodimethylamine in the Rat A. Aramphongphan P. Navasumrit Y. Kuroiwa T. Yoshida N. Frank M. Ruchirawat Mahidol University Chulabhorn Research Institute Showa University German Cancer Research Center Medicine Nursing The alteration in the metabolic activation of N-nitroso-dimethylamine (NDMA) was investigated in the rat during dietary pyridoxine deficiency. The in vitro metabolism of NDMA by demethylase system was measured in both liver and kidney microsomes. The profile of the kidney enzyme appears similar to that of the liver indicating that at least two forms of isozymes with the low and the high Km's are present. Pyridoxine deficiency significantly increased the activity of NDMA-demthylase of both organs. The increase in the activity of NDMA-demethylase induced by dietary pyridoxine deficiency can be reversed by supplementation of pyridoxine (500μg), i.p., daily for two consecutive days. The increase ia the NADPH cytochrome c reductase activity was observed after 6 weeks on pyridoxine-deficient diet. © 1994, Center for Academic Publications Japan. All rights reserved. 2018-02-27T04:29:20Z 2018-02-27T04:29:20Z 1994-01-01 Article Journal of Nutritional Science and Vitaminology. Vol.40, No.2 (1994), 105-113 10.3177/jnsv.40.105 18817742 03014800 2-s2.0-0028305774 https://repository.li.mahidol.ac.th/handle/123456789/9830 Mahidol University SCOPUS https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=0028305774&origin=inward
institution Mahidol University
building Mahidol University Library
continent Asia
country Thailand
Thailand
content_provider Mahidol University Library
collection Mahidol University Institutional Repository
topic Medicine
Nursing
spellingShingle Medicine
Nursing
A. Aramphongphan
P. Navasumrit
Y. Kuroiwa
T. Yoshida
N. Frank
M. Ruchirawat
Effects of Pyridoxine Deficiency on the Metabolism of N-Nitrosodimethylamine in the Rat
description The alteration in the metabolic activation of N-nitroso-dimethylamine (NDMA) was investigated in the rat during dietary pyridoxine deficiency. The in vitro metabolism of NDMA by demethylase system was measured in both liver and kidney microsomes. The profile of the kidney enzyme appears similar to that of the liver indicating that at least two forms of isozymes with the low and the high Km's are present. Pyridoxine deficiency significantly increased the activity of NDMA-demthylase of both organs. The increase in the activity of NDMA-demethylase induced by dietary pyridoxine deficiency can be reversed by supplementation of pyridoxine (500μg), i.p., daily for two consecutive days. The increase ia the NADPH cytochrome c reductase activity was observed after 6 weeks on pyridoxine-deficient diet. © 1994, Center for Academic Publications Japan. All rights reserved.
author2 Mahidol University
author_facet Mahidol University
A. Aramphongphan
P. Navasumrit
Y. Kuroiwa
T. Yoshida
N. Frank
M. Ruchirawat
format Article
author A. Aramphongphan
P. Navasumrit
Y. Kuroiwa
T. Yoshida
N. Frank
M. Ruchirawat
author_sort A. Aramphongphan
title Effects of Pyridoxine Deficiency on the Metabolism of N-Nitrosodimethylamine in the Rat
title_short Effects of Pyridoxine Deficiency on the Metabolism of N-Nitrosodimethylamine in the Rat
title_full Effects of Pyridoxine Deficiency on the Metabolism of N-Nitrosodimethylamine in the Rat
title_fullStr Effects of Pyridoxine Deficiency on the Metabolism of N-Nitrosodimethylamine in the Rat
title_full_unstemmed Effects of Pyridoxine Deficiency on the Metabolism of N-Nitrosodimethylamine in the Rat
title_sort effects of pyridoxine deficiency on the metabolism of n-nitrosodimethylamine in the rat
publishDate 2018
url https://repository.li.mahidol.ac.th/handle/123456789/9830
_version_ 1763492378440630272

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