Prediction, prevention, and mechanism of early (anaphylactic) antivenom reactions in victims of snake bites
Victims of snake bites are often subjected to cutaneous or conjunctival hypersensitivity testing before being given antivenom. None of 12 early (anaphylactic) reactions was predicted by these tests in 25 Nigerian and Thai patients. The incidence and severity of early reactions was the same whether a...
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th-mahidol.98572018-02-27T11:29:47Z Prediction, prevention, and mechanism of early (anaphylactic) antivenom reactions in victims of snake bites Prida Malasit D. A. Warrell Pornthep Chanthavanich Chaisin Viravan Juthathip Mongkolsapaya Benjawan Singhthong Chalida Supich Mahidol University Thai Red Cross Agency Medicine Victims of snake bites are often subjected to cutaneous or conjunctival hypersensitivity testing before being given antivenom. None of 12 early (anaphylactic) reactions was predicted by these tests in 25 Nigerian and Thai patients. The incidence and severity of early reactions was the same whether antivenom was given by intravenous injection over 10 minutes or diluted and given as an intravenous infusion over 30 minutes. Although antivenom activated complement in vitro, there was no evidence of complement activation or formation of immune complexes in patients bitten by snakes who were treated with antivenom, whether or not they developed early reactions. Higher doses of antivenom might induce the complement activation and formation of immune complexes (aggregates) that have been observed during the clinically more severe reactions associated with homologous immunoglobulin treatment. © 1986, British Medical Journal Publishing Group. All rights reserved. 2018-02-27T04:29:47Z 2018-02-27T04:29:47Z 1986-01-01 Article British Medical Journal (Clinical research ed.). Vol.292, No.6512 (1986), 17-20 10.1136/bmj.292.6512.17 02670623 2-s2.0-0022655993 https://repository.li.mahidol.ac.th/handle/123456789/9857 Mahidol University SCOPUS https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=0022655993&origin=inward |
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Medicine Prida Malasit D. A. Warrell Pornthep Chanthavanich Chaisin Viravan Juthathip Mongkolsapaya Benjawan Singhthong Chalida Supich Prediction, prevention, and mechanism of early (anaphylactic) antivenom reactions in victims of snake bites |
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Victims of snake bites are often subjected to cutaneous or conjunctival hypersensitivity testing before being given antivenom. None of 12 early (anaphylactic) reactions was predicted by these tests in 25 Nigerian and Thai patients. The incidence and severity of early reactions was the same whether antivenom was given by intravenous injection over 10 minutes or diluted and given as an intravenous infusion over 30 minutes. Although antivenom activated complement in vitro, there was no evidence of complement activation or formation of immune complexes in patients bitten by snakes who were treated with antivenom, whether or not they developed early reactions. Higher doses of antivenom might induce the complement activation and formation of immune complexes (aggregates) that have been observed during the clinically more severe reactions associated with homologous immunoglobulin treatment. © 1986, British Medical Journal Publishing Group. All rights reserved. |
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Mahidol University |
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Mahidol University Prida Malasit D. A. Warrell Pornthep Chanthavanich Chaisin Viravan Juthathip Mongkolsapaya Benjawan Singhthong Chalida Supich |
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Article |
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Prida Malasit D. A. Warrell Pornthep Chanthavanich Chaisin Viravan Juthathip Mongkolsapaya Benjawan Singhthong Chalida Supich |
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Prida Malasit |
title |
Prediction, prevention, and mechanism of early (anaphylactic) antivenom reactions in victims of snake bites |
title_short |
Prediction, prevention, and mechanism of early (anaphylactic) antivenom reactions in victims of snake bites |
title_full |
Prediction, prevention, and mechanism of early (anaphylactic) antivenom reactions in victims of snake bites |
title_fullStr |
Prediction, prevention, and mechanism of early (anaphylactic) antivenom reactions in victims of snake bites |
title_full_unstemmed |
Prediction, prevention, and mechanism of early (anaphylactic) antivenom reactions in victims of snake bites |
title_sort |
prediction, prevention, and mechanism of early (anaphylactic) antivenom reactions in victims of snake bites |
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2018 |
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https://repository.li.mahidol.ac.th/handle/123456789/9857 |
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1763494341112758272 |