Biological Activity of Chemical Constituents from Cinnamomum porrecyum (Roxb.) Kosterm
Master of Science (Applied Chemistry), 2023
Saved in:
| Main Author: | |
|---|---|
| Other Authors: | |
| Format: | Theses and Dissertations |
| Language: | English |
| Published: |
Prince of Songkla University
2024
|
| Subjects: | |
| Online Access: | http://kb.psu.ac.th/psukb/handle/2016/19447 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Institution: | Prince of Songkhla University |
| Language: | English |
| id |
th-psu.2016-19447 |
|---|---|
| record_format |
dspace |
| spelling |
th-psu.2016-194472024-06-06T04:37:26Z Biological Activity of Chemical Constituents from Cinnamomum porrecyum (Roxb.) Kosterm ฤทธิ์ทางชีวภาพขององค์ประกอบทางเคมีจากต้นเทพทาโร Pornpimoll Muanchaichum Parinuch Chumkaew Faculty of Science and Industrial Technology คณะวิทยาศาสตร์และเทคโนโลยีอุตสาหกรรม Cinnamomum porrectum (Roxb.) Kosterm Antibacterial activity Antioxidant activity Phenylpropanoids Plant pathogenic fungal Master of Science (Applied Chemistry), 2023 Cinnamomum porrectum (Roxb.) Kosterm (Theptaro) is a aromatic tree. Mostly of the species are in the throughout southern Thailand and have medicinal properties such as helping to resolve diarrhea, flatulence, dizziness and vomiting. The purpose of this study was to isolate pure compounds from crude extracts the roots and barks of C. porrectum and assess for antibacterial activities, plant pathogenic fungal and antioxidant activity of crude extracts and pure compounds from the roots and barks. Air-dried roots and bark of C. porrectum to maceratied with dichloromethane and acetone. The results revealed that the pure compounds could be isolated from crude extracts the roots and barks and contains phenylpropanoid derivatives.Six compounds wereisolated including Safrole(CP1), 3,4 Methylenedioxy cinnamaldehyde (CP2), n-Butyl ferulate (CP3), 3-(3,4 Methylenedioxyphenyl)-1,2-propanediol ( CP4) , Elemicin ( CP5) and 3,4-(Methylenedioxy) cinnamyl Alcohol ( CP6) . Their structures were characterized of these compounds based on 1 H and 13C NMR spectroscopy data and compared with data of the previously reported. The crude extracts of dichloromethane, acetone and all six compounds have been evaluated for antibacterial activity of 4 bacteria species: Staphylococcus aureus (ATCC25923), Bacillus cereus (ATCC11778), Pseudomonas aeruginosa (ATCC27853) and Escherichia coli (ATCC25922). The results revealed that dichloromethane extracts of the roots and barks were showing a good inhibition in the region of B. cereus (ATCC11778) values of 22.33 and 17.00 mm respectively. CP6 showed activity in inhibitingS. aureusand B. cereus with MIC values of 1,000 and 2,000 µg/ml respectively. more effectively than CP4 which showed inhibition potential against S. aureus and B. cereus with equal MIC values of 2000 µg/ml for antifungal activity. To investigate the plant pathogenic fungal, The results were found that dichloromethane root extracts from C. porrectum at concentrations of 10, 5, 1 mg/ml showed best activities to inhibit the growth of A. alternata at 48.86 – 100.00 percent. All compounds exhibited weak activity against A. alternata with MIC values of greater than 100 µg/ml. Antioxidant activity assays by using DPPH (1, 1-diphenyl-2- picrylhydrazyl) radical scavenging activity assay method, test results found that n-Butyl ferulate has the best antioxidant activity. The inhibitory concentration at 50%, IC50 values of CP3 were 55.52 mg/ml. 2024-06-06T04:36:57Z 2024-06-06T04:36:57Z 2023 Thesis http://kb.psu.ac.th/psukb/handle/2016/19447 en Attribution-NonCommercial-NoDerivs 3.0 Thailand http://creativecommons.org/licenses/by-nc-nd/3.0/th/ application/pdf Prince of Songkla University |
| institution |
Prince of Songkhla University |
| building |
Khunying Long Athakravi Sunthorn Learning Resources Center |
| continent |
Asia |
| country |
Thailand Thailand |
| content_provider |
Khunying Long Athakravi Sunthorn Learning Resources Center |
| collection |
PSU Knowledge Bank |
| language |
English |
| topic |
Cinnamomum porrectum (Roxb.) Kosterm Antibacterial activity Antioxidant activity Phenylpropanoids Plant pathogenic fungal |
| spellingShingle |
Cinnamomum porrectum (Roxb.) Kosterm Antibacterial activity Antioxidant activity Phenylpropanoids Plant pathogenic fungal Pornpimoll Muanchaichum Biological Activity of Chemical Constituents from Cinnamomum porrecyum (Roxb.) Kosterm |
| description |
Master of Science (Applied Chemistry), 2023 |
| author2 |
Parinuch Chumkaew |
| author_facet |
Parinuch Chumkaew Pornpimoll Muanchaichum |
| format |
Theses and Dissertations |
| author |
Pornpimoll Muanchaichum |
| author_sort |
Pornpimoll Muanchaichum |
| title |
Biological Activity of Chemical Constituents from Cinnamomum porrecyum (Roxb.) Kosterm |
| title_short |
Biological Activity of Chemical Constituents from Cinnamomum porrecyum (Roxb.) Kosterm |
| title_full |
Biological Activity of Chemical Constituents from Cinnamomum porrecyum (Roxb.) Kosterm |
| title_fullStr |
Biological Activity of Chemical Constituents from Cinnamomum porrecyum (Roxb.) Kosterm |
| title_full_unstemmed |
Biological Activity of Chemical Constituents from Cinnamomum porrecyum (Roxb.) Kosterm |
| title_sort |
biological activity of chemical constituents from cinnamomum porrecyum (roxb.) kosterm |
| publisher |
Prince of Songkla University |
| publishDate |
2024 |
| url |
http://kb.psu.ac.th/psukb/handle/2016/19447 |
| _version_ |
1802995673067421696 |