Formulation Development of Nicotinamide Microemulsions Using Natural Oils as Oil Phase

Master of Pharmaceutical Sciences (Cosmetic Sciences (International Program)),2019

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Main Author: Nang Hnin Ei Hlaing
Other Authors: Prapaporn Boonme
Format: Theses and Dissertations
Language:English
Published: Prince of Songkla University 2024
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Online Access:http://kb.psu.ac.th/psukb/handle/2016/19483
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Institution: Prince of Songkhla University
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spelling th-psu.2016-194832024-06-19T03:26:42Z Formulation Development of Nicotinamide Microemulsions Using Natural Oils as Oil Phase Nang Hnin Ei Hlaing Prapaporn Boonme Faculty of Pharmaceutical Sciences (Pharmaceutical Chemistry) คณะเภสัชศาสตร์ ภาควิชาเภสัชเคมี Cosmetics Skin Care and hygiene Master of Pharmaceutical Sciences (Cosmetic Sciences (International Program)),2019 Concerning the conservation of ecosystem, biodegradable and environmental friendly chemicals have been chosen to formulate as green microemulsions (MEs). The objective of this research was to investigate phase behavior of nonionic surfactants with natural oils on formation of green MEs. In this study, MEs were formulated from olive oil or virgin coconut oil with various ratios of surfactant mixture (Smix) between polyoxyethylene (20) sorbitan monooleate (Tween 80) and sorbitan monooleate (Span 80). The formulation scanning was carried out based on hydrophilic lipophilic deviation (HLD) concept followed by titration method. From the obtained pseudotenary phase diagrams, surfactant:cosurfactant (S:COS) ratios of 0.6:0.4 and 0.7:0.3 were chosen as Smix. The compositions of blank MES were 45% w/w of oil, 50% w/w of Smix and 5% w/w of water. The visual and technical characterization of formulations indicated that all MEs were water-in-oil (w/o) type. After accelerating stability test, 3% w/w of nicotinamide was added to blank MES to obtain MEO1-N, MEO2-N, MEC1-N and MEC2-N. They were characterized as w/o MEs. Afterward, samples were kept at 4°C, room temperature (28 ± 2°C) and 45°C for three months to study physical and chemical stabilities. MEO2-N got phase separation since the first month of storage at all conditions due to enlarged entropy. The drug remaining content was assayed by HPLC method and more than 90% of active was detected in MEO1-N, MEC1-N and MEC2- N kept at 4°C and room temperature. High temperature, 45°C, caused discoloration in all formulations. The in vitro release profiles of MEO1-N and MEC1-N were compared with 3% w/w nicotinamide solution (NCT sol). After 12 h, NCT sol reached a plateau while MEO1-N and MEC1-N provided the sustained release profiles which were best fitted to the Higuchi model. The release rate of MEO1-N was higher than MEC1-N because of the board intermolecular area of fatty acid chain allowing nicotinamide to diffuse better. The in vitro release kinetics of after three months stored MEs also followed the Higuchi model and the release rate was significantly different to freshly prepared MEs (p <0.05, t-test). The current observation revealed that not only HLB but also the degree of saturation of fatty acids, water-to-lipid ratio and S:COS ratio influenced the formation of MES type and stability. The in vitro release rate was affected by the oil type when the same Smix was applied. These natural oil microemulsions were promising as nanocarriers of nicotinamide. Moreover, they could be further observed for incorporation of other active ingredients and effectiveness of active delivery to the skin. Higher Education Research Promotion and the Thailand's Education Hub for Southern Region of ASEAN Countries Project Office of the Higher Education Commission (TEH-AC 020/2017) 2024-06-19T03:24:48Z 2024-06-19T03:24:48Z 2019 Thesis http://kb.psu.ac.th/psukb/handle/2016/19483 en Attribution-NonCommercial-NoDerivs 3.0 Thailand http://creativecommons.org/licenses/by-nc-nd/3.0/th/ application/pdf Prince of Songkla University
institution Prince of Songkhla University
building Khunying Long Athakravi Sunthorn Learning Resources Center
continent Asia
country Thailand
Thailand
content_provider Khunying Long Athakravi Sunthorn Learning Resources Center
collection PSU Knowledge Bank
language English
topic Cosmetics
Skin Care and hygiene
spellingShingle Cosmetics
Skin Care and hygiene
Nang Hnin Ei Hlaing
Formulation Development of Nicotinamide Microemulsions Using Natural Oils as Oil Phase
description Master of Pharmaceutical Sciences (Cosmetic Sciences (International Program)),2019
author2 Prapaporn Boonme
author_facet Prapaporn Boonme
Nang Hnin Ei Hlaing
format Theses and Dissertations
author Nang Hnin Ei Hlaing
author_sort Nang Hnin Ei Hlaing
title Formulation Development of Nicotinamide Microemulsions Using Natural Oils as Oil Phase
title_short Formulation Development of Nicotinamide Microemulsions Using Natural Oils as Oil Phase
title_full Formulation Development of Nicotinamide Microemulsions Using Natural Oils as Oil Phase
title_fullStr Formulation Development of Nicotinamide Microemulsions Using Natural Oils as Oil Phase
title_full_unstemmed Formulation Development of Nicotinamide Microemulsions Using Natural Oils as Oil Phase
title_sort formulation development of nicotinamide microemulsions using natural oils as oil phase
publisher Prince of Songkla University
publishDate 2024
url http://kb.psu.ac.th/psukb/handle/2016/19483
_version_ 1802995680225001472