The HDAC inhibitor SB939 overcomes resistance to BCR-ABL kinase Inhibitors conferred by the BIM deletion polymorphism in chronic myeloid leukemia

by Rauzan M., Chuah C.T.H., Ko T.K., Tiong Ong S.
Published 2020

High-throughput genotyping of CRISPR/Cas9-mediated mutants using fluorescent PCR-capillary gel electrophoresis

by Ramlee, M.K, Yan, T, Cheung, A.M.S, Chuah, C.T.H, Li, S
Published 2020

Physiologic hypoxia promotes maintenance of CML stem cells despite effective BCR-ABL1 inhibition

by Ng K.P., Manjeri A., Lee K.L., Huang W., Tan S.Y., Chuah C.T.H., Poellinger L., Ong S.T.
Published 2020

The BIM deletion polymorphism: A paradigm of a permissive interaction between germline and acquired TKI resistance factors in chronic myeloid leukemia

by Ko T.K., Chin H.S., Chuah C.T.H., Huang J.W.J., Ng K.-P., Khaw S.L., Huang D.C.S., Ong S.T.
Published 2020

A novel Bcr-Abl-mtor-eIF4a axis regulates IRES-mediated translation of LEF-1

by Tsai B.P., Jimenez J., Lim S., Fitzgerald K.D., Zhang M., Chuah C.T.H., Axelrod H., Nelson L., Ong S.T., Semler B.L., Waterman M.L.
Published 2018

Targeting of the MNK-eIF4E axis in blast crisis Chronic myeloid leukemia inhibits leukemia stem cell function

by Lim, S., Saw, T.Y., Zhang, M., Janes, M.R., Nacro, K., Hill, J., Lim, A.Q., Chang, C.-T., Fruman, D.A., Rizzieri, D.A., Tan, S.Y., Fan, H., Chuah, C.T.H., Ong, S.T.
Published 2014

A common BIM deletion polymorphism mediates intrinsic resistance and inferior responses to tyrosine kinase inhibitors in cancer

by Ng, K.P., Hillmer, A.M., Chuah, C.T.H., Juan, W.C., Ko, T.K., Teo, A.S.M., Ariyaratne, P.N., Takahashi, N., Sawada, K., Fei, Y., Soh, S., Lee, W.H., Huang, J.W.J., Allen Jr., J.C., Woo, X.Y., Nagarajan, N., Kumar, V., Thalamuthu, A., Poh, W.T., Ang, A.L., Mya, H.T., How, G.F., Yang, L.Y., Koh, L.P., Chowbay, B., Chang, C.-T., Nadarajan, V.S., Chng, W.J., Than, H., Lim, L.C., Goh, Y.T., Zhang, S., Poh, D., Tan, P., Seet, J.-E., Ang, M.-K., Chau, N.-M., Ng, Q.-S., Tan, D.S.W., Soda, M., Isobe, K., Nöthen, M.M., Wong, T.Y., Shahab, A., Ruan, X., Cacheux-Rataboul, V., Sung, W.-K., Tan, E.H., Yatabe, Y., Mano, H., Soo, R.A., Chin, T.M., Lim, W.-T., Ruan, Y., Ong, S.T.
Published 2014