Monoclonal antibodies, derived from humans vaccinated with the RV144 HIV vaccine containing the HVEM binding domain of herpes simplex virus (HSV) glycoprotein D, neutralize HSV inf...

by Kening Wang, Georgia D. Tomaras, Sinthujan Jegaskanda, M. Anthony Moody, Hua Xin Liao, Kyle N. Goodman, Phillip W. Berman, Supachai Rerks-Ngarm, Punnee Pitisuttithum, Sorachai Nitayapan, Jaranit Kaewkungwal, Barton F. Haynes, Jeffrey I. Cohena
Published 2018

Monocyte-derived transcriptome signature indicates antibody-dependent cellular phagocytosis as a potential mechanism of vaccine-induced protection against hiv-1

by Shida Shangguan, Philip K. Ehrenberg, Aviva Geretz, Lauren Yum, Gautam Kundu, Kelly May, Slim Fourati, Krystelle Nganou-Makamdop, Latonya D. Williams, Sheetal Sawant, Eric Lewitus, Punnee Pitisuttithum, Sorachai Nitayaphan, Suwat Chariyalertsak, Supachai Rerks-Ngarm, Morgane Rolland, Daniel Douek, Peter Gilbert, Georgia D. Tomaras, Nelson Michael, Sandhya Vasan, Rasmi Thomas
Published 2022

Integrated systems approach defines the antiviral pathways conferring protection by the RV144 HIV vaccine

by Slim Fourati, Susan Pereira Ribeiro, Filipa Blasco Tavares Pereira Lopes, Aarthi Talla, Francois Lefebvre, Mark Cameron, J. Kaewkungwal, P. Pitisuttithum, S. Nitayaphan, S. Rerks-Ngarm, Jerome H. Kim, Rasmi Thomas, Peter B. Gilbert, Georgia D. Tomaras, Richard A. Koup, Nelson L. Michael, M. Juliana McElrath, Raphael Gottardo, Rafick Pierre Sékaly
Published 2020

Vaccine-induced HIV-1 envelope gp120 constant region 1-specific antibodies expose a CD4-inducible epitope and block the interaction of HIV-1 gp140 with galactosylceramide

by S. Moses Dennison, Kara M. Anasti, Frederick H. Jaeger, Shelley M. Stewart, Justin Pollara, Pinghuang Liu, Erika L. Kunz, Ruijun Zhang, Nathan Vandergrift, Sallie Permar, Guido Ferrari, Georgia D. Tomaras, Mattia Bonsignori, Nelson L. Michael, Jerome H. Kim, Jaranit Kaewkungwal, Sorachai Nitayaphan, Punnee Pitisuttithum, Supachai Rerks-Ngarm, Hua Xin Liao, Barton F. Haynes, S. Munir Alam
Published 2018

HIV-1 envelope glycoproteins from diverse clades differentiate antibody responses and durability among vaccinees

by Nicole L. Yates, Allan C. deCamp, Bette T. Korber, Hua Xin Liao, Carmela Irene, Abraham Pinter, James Peacock, Linda J. Harris, Sheetal Sawant, Peter Hraber, Xiaoying Shen, Supachai Rerks-Ngarm, Punnee Pitisuttithum, Sorachai Nitayapan, Phillip W. Berman, Merlin L. Robb, Giuseppe Pantaleo, Susan Zolla-Pazner, Barton F. Haynes, S. Munir Alam, David C. Montefiori, Georgia D. Tomaras
Published 2019

Vaccine-induced plasma IgA specific for the C1 region of the HIV-1 envelope blocks binding and effector function of IgG

by Georgia D. Tomaras, Guido Ferrari, Xiaoying Shen, S. Munir Alam, Hua Xin Liao, Justin Pollara, Mattia Bonsignori, M. Anthony Moody, Youyi Fong, Xi Chen, Brigid Poling, Cindo O. Nicholson, Ruijun Zhang, Xiaozhi Lu, Robert Parks, Jaranit Kaewkungwal, Sorachai Nitayaphan, Punnee Pitisuttithum, Supachai Rerks-Ngarm, Peter B. Gilbert, Jerome H. Kim, Nelson L. Michael, David C. Montefiori, Barton F. Haynes
Published 2018

Infectious virion capture by HIV-1 gp120-specific IgG from RV144 vaccinees

by Pinghuang Liu, Nicole L. Yates, Xiaoying Shen, Mattia Bonsignori, M. Anthony Moody, Hua Xin Liao, Youyi Fong, S. Munir Alam, R. Glenn Overman, Thomas Denny, Guido Ferrari, Christina Ochsenbauer, John C. Kappes, Victoria R. Polonis, Punnee Pitisuttithum, Jaranit Kaewkungwal, Sorachai Nitayaphan, Supachai Rerks-Ngarm, David C. Montefiori, Peter Gilbert, Nelson L. Michael, Jerome H. Kim, Barton F. Haynes, Georgia D. Tomaras
Published 2018

COMPASS identifies T-cell subsets correlated with clinical outcomes

by Lin Lin, Greg Finak, Kevin Ushey, Chetan Seshadri, Thomas R. Hawn, Nicole Frahm, Thomas J. Scriba, Hassan Mahomed, Willem Hanekom, Pierre Alexandre Bart, Giuseppe Pantaleo, Georgia D. Tomaras, Supachai Rerks-Ngarm, Jaranit Kaewkungwal, Sorachai Nitayaphan, Punnee Pitisuttithum, Nelson L. Michael, Jerome H. Kim, Merlin L. Robb, Robert J. O'Connell, Nicos Karasavvas, Peter Gilbert, Stephen C. De Rosa, M. Juliana McElrath, Raphael Gottardo
Published 2018

HIV-1 vaccine-induced C1 and V2 Env-specific antibodies synergize for increased antiviral activities

by Justin Pollara, Mattia Bonsignori, M. Anthony Moody, Pinghuang Liu, S. Munir Alam, Kwan Ki Hwang, Thaddeus C. Gurley, Daniel M. Kozink, Lawrence C. Armand, Dawn J. Marshall, John F. Whitesides, Jaranit Kaewkungwal, Sorachai Nitayaphan, Punnee Pitisuttithum, Supachai Rerks-Ngarm, Merlin L. Robb, Robert J. O'Connell, Jerome H. Kim, Nelson L. Michael, David C. Montefiori, Georgia D. Tomaras, Hua Xin Liao, Barton F. Haynes, Guido Ferrari
Published 2018

HIV-1- specific IgA monoclonal antibodies from an HIV-1 vaccinee mediate galactosylceramide blocking and phagocytosis

by Saintedym Wills, Kwan Ki Hwang, Pinghuang Liu, S. Moses Dennison, Matthew Zirui Tay, Xiaoying Shen, Justin Pollara, Judith T. Lucas, Robert Parks, Supachai Rerks-Ngarm, Punnee Pitisuttithum, Sorachai Nitayapan, Jaranit Kaewkungwal, Rasmi Thomas, Jerome H. Kim, Nelson L. Michael, Merlin L. Robb, Mike McRaven, David C. Montefiori, Thomas J. Hope, Hua Xin Liao, M. Anthony Moody, Guido Ferrari, Barton F. Haynes, S. Munir Alam, Mattia Bonsignori, Georgia D. Tomaras
Published 2019

Antibody to HSV gD peptide induced by vaccination does not protect against HSV-2 infection in HSV-2 seronegative women

by Peter B. Gilbert, Jean Louis Excler, Georgia D. Tomaras, Lindsay N. Carpp, Barton F. Haynes, Hua Xin Liao, David C. Montefiori, Supachai Rerks-Ngarm, Punnee Pitisuttithum, Sorachai Nitayaphan, Jaranit Kaewkungwal, Gustavo H. Kijak, Sodsai Tovanabutra, Donald P. Francis, Carter Lee, Faruk Sinangil, Phillip W. Berman, Nakorn Premsri, Prayura Kunasol, Robert J. O'Connell, Nelson L. Michael, Merlin L. Robb, Rhoda Morrow, Lawrence Corey, Jerome H. Kim
Published 2018

Plasma IgG to Linear Epitopes in the V2 and V3 Regions of HIV-1 gp120 Correlate with a Reduced Risk of Infection in the RV144 Vaccine Efficacy Trial

by Raphael Gottardo, Robert T. Bailer, Bette T. Korber, S. Gnanakaran, Joshua Phillips, Xiaoying Shen, Georgia D. Tomaras, Ellen Turk, Gregory Imholte, Larry Eckler, Holger Wenschuh, Johannes Zerweck, Kelli Greene, Hongmei Gao, Phillip W. Berman, Donald Francis, Faruk Sinangil, Carter Lee, Sorachai Nitayaphan, Supachai Rerks-Ngarm, Jaranit Kaewkungwal, Punnee Pitisuttithum, James Tartaglia, Merlin L. Robb, Nelson L. Michael, Jerome H. Kim, Susan Zolla-Pazner, Barton F. Haynes, John R. Mascola, Steve Self, Peter Gilbert, David C. Montefiori
Published 2018

Boosting with AIDSvax B/E enhances Env constant region 1 and 2 antibody-dependent cellular cytotoxicity breadth and potency

by David Easterhoff, Justin Pollara, Kan Luo, William D. Tolbert, Brianna Young, Dieter Mielke, Shalini Jha, Robert J. O’Connell, Sandhya Vasan, Jerome Kim, Nelson L. Michael, Jean Louis Excler, Merlin L. Robb, Supachai Rerks-Ngarm, Jaranit Kaewkungwal, Punnee Pitisuttithum, Sorachai Nitayaphan, Faruk Sinangil, James Tartaglia, Sanjay Phogat, Thomas B. Kepler, S. Munir Alam, Kevin Wiehe, Kevin O. Saunders, David C. Montefiori, Georgia D. Tomaras, M. Anthony Moody, Marzena Pazgier, Barton F. Haynes, Guido Ferrari
Published 2020

Landscapes of binding antibody and T-cell responses to pox-protein HIV vaccines in Thais and South Africans

by Lue Ping Zhao, Andrew Fiore-Gartland, Lindsay N. Carpp, Kristen W. Cohen, Nadine Rouphael, Llewellyn Fleurs, One Dintwe, Michael Zhao, Zoe Moodie, Youyi Fong, Nigel Garrett, Ying Huang, Craig Innes, Holly E. Janes, Erica Lazarus, Nelson L. Michael, Sorachai Nitayaphan, Punnee Pitisuttithum, Supachai Rerks-Ngarm, Merlin L. Robb, Stephen C. de Rosa, Lawrence Corey, Glenda E. Gray, Kelly E. Seaton, Nicole L. Yates, M. Juliana McElrath, Nicole Frahm, Georgia D. Tomaras, Peter B. Gilbert
Published 2020

Neutralization Takes Precedence Over IgG or IgA Isotype-related Functions in Mucosal HIV-1 Antibody-mediated Protection

by Rena D. Astronomo, Sampa Santra, Lamar Ballweber-Fleming, Katharine G. Westerberg, Linh Mach, Tiffany Hensley-McBain, Laura Sutherland, Benjamin Mildenberg, Georgeanna Morton, Nicole L. Yates, Gregory J. Mize, Justin Pollara, Florian Hladik, Christina Ochsenbauer, Thomas N. Denny, Ranjit Warrier, Supachai Rerks-Ngarm, Punnee Pitisuttithum, Sorachai Nitayapan, Jaranit Kaewkungwal, Guido Ferrari, George M. Shaw, Shi Mao Xia, Hua Xin Liao, David C. Montefiori, Georgia D. Tomaras, Barton F. Haynes, M. Juliana McElrath
Published 2018

Antibody-dependent cellular cytotoxicity-mediating antibodies from an HIV-1 vaccine efficacy trial target multiple epitopes and preferentially use the VH1 gene family

by Mattia Bonsignori, Justin Pollara, Anthony A. Moody, Xi Chen, Kwan Ki Hwang, Thaddeus C. Gurley, Daniel M. Kozink, Dawn J. Marshall, John F. Whitesides, Chun Yen Tsao, Georgia D. Tomaras, David C. Montefiori, Guido Ferrari, Hua Xin Liao, Barton F. Haynes, Michael D. Alpert, David T. Evans, Peter B. Gilbert, Ying Huang, Jaranit Kaewkungwal, Sorachai Nitayaphan, Punnee Pitisuttithum, Supachai Rerks-Ngarm, Jerome H. Kim, Nelson L. Michael, George K. Lewis, Anthony DeVico
Published 2018

HLA class II genes modulate vaccine-induced antibody responses to affect HIV-1 acquisition

by Heather A. Prentice, Georgia D. Tomaras, Daniel E. Geraghty, Richard Apps, Youyi Fong, Philip K. Ehrenberg, Morgane Rolland, Gustavo H. Kijak, Shelly J. Krebs, Wyatt Nelson, Allan DeCamp, Xiaoying Shen, Nicole L. Yates, Susan Zolla-Pazner, Sorachai Nitayaphan, Supachai Rerks-Ngarm, Jaranit Kaewkungwal, Punnee Pitisuttithum, Guido Ferrari, M. Juliana McElrath, David C. Montefiori, Robert T. Bailer, Richard A. Koup, Robert J. O'Connell, Merlin L. Robb, Nelson L. Michael, Peter B. Gilbert, Jerome H. Kim, Rasmi Thomas
Published 2018

Antibody light-chain-restricted recognition of the site of immune pressure in the RV144 HIV-1 vaccine trial is phylogenetically conserved

by Kevin Wiehe, David Easterhoff, Kan Luo, Nathan I. Nicely, Todd Bradley, Frederick H. Jaeger, S. Moses Dennison, Ruijun Zhang, Krissey E. Lloyd, Christina Stolarchuk, Robert Parks, Laura L. Sutherland, Richard M. Scearce, Lynn Morris, Jaranit Kaewkungwal, Sorachai Nitayaphan, Punnee Pitisuttithum, Supachai Rerks-Ngarm, Faruk Sinangil, Sanjay Phogat, Nelson L. Michael, Jerome H. Kim, Garnett Kelsoe, David C. Montefiori, Georgia D. Tomaras, Mattia Bonsignori, Sampa Santra, Thomas B. Kepler, S. Munir Alam, M. Anthony Moody, Hua Xin Liao, Barton F. Haynes
Published 2018

Boosting of HIV envelope CD4 binding site antibodies with long variable heavy third complementarity determining region in the randomized double blind RV305 HIV-1 vaccine trial

by David Easterhoff, M. Anthony Moody, Daniela Fera, Hao Cheng, Margaret Ackerman, Kevin Wiehe, Kevin O. Saunders, Justin Pollara, Nathan Vandergrift, Rob Parks, Jerome Kim, Nelson L. Michael, Robert J. O’Connell, Jean Louis Excler, Merlin L. Robb, Sandhya Vasan, Supachai Rerks-Ngarm, Jaranit Kaewkungwal, Punnee Pitisuttithum, Sorachai Nitayaphan, Faruk Sinangil, James Tartaglia, Sanjay Phogat, Thomas B. Kepler, S. Munir Alam, Hua Xin Liao, Guido Ferrari, Michael S. Seaman, David C. Montefiori, Georgia D. Tomaras, Stephen C. Harrison, Barton F. Haynes
Published 2018

Antigenicity and immunogenicity of RV144 vaccine AIDSVAX clade E envelope immunogen is enhanced by a gp120 N-terminal deletion

by Munir S. Alam, Hua Xin Liao, Georgia D. Tomaras, Mattia Bonsignori, Chun Yen Tsao, Kwan Ki Hwang, Haiyan Chen, E. Lloyd Krissey E., Cindy Bowman, Laura Sutherland, Thomas L. Jeffries, Daniel M. Kozink, Shelley Stewart, Kara Anasti, Frederick H. Jaeger, Robert Parks, Nicole L. Yates, Glenn R. Overman, Faruk Sinangil, Phillip W. Berman, Punnee Pitisuttithum, Jaranit Kaewkungwal, Sorachai Nitayaphan, Nicos Karasavva, Supachai Rerks-Ngarm, Jerome H. Kim, Nelson L. Michael, Susan Zolla-Pazner, Sampa Santra, Norman L. Letvin, Stephen C. Harrison, Barton F. Haynes
Published 2018