Characterization of HIV-1 gp120 antibody specificities induced in anogenital secretions of RV144 vaccine recipients after late boost immunizations

by Siriwat Akapirat, Chitraporn Karnasuta, Sandhya Vasan, Supachai Rerks-Ngarm, Punnee Pitisuttithum, Sirinan Madnote, Hathairat Savadsuk, Surawach Rittiroongrad, Jiraporn Puangkaew, Sanjay Phogat, James Tartaglia, Faruk Sinangil, Mark S. de Souza, Jean Louis Excler, Jerome H. Kim, Merlin L. Robb, Nelson L. Michael, Viseth Ngauy, Robert J. O’Connell, Nicos Karasavvas
Published 2019

Comparison of antibody responses induced by RV144, VAX003, and VAX004 vaccination regimens

by Chitraporn Karnasuta, Siriwat Akapirat, Sirinan Madnote, Hathairat Savadsuk, Jiraporn Puangkaew, Surawach Rittiroongrad, Supachai Rerks-Ngarm, Sorachai Nitayaphan, Punnee Pitisuttithum, Jaranit Kaewkungwal, James Tartaglia, Faruk Sinangil, Donald P. Francis, Merlin L. Robb, Mark S. De Souza, Nelson L. Michael, Jean Louis Excler, Jerome H. Kim, Robert J. O'connell, Nicos Karasavvas
Published 2018

IgG Antibody Responses to Recombinant gp120 Proteins, gp70V1/V2 Scaffolds, and a CyclicV2 Peptide in Thai Phase I/II Vaccine Trials Using Different Vaccine Regimens

by Nicos Karasavvas, Chitraporn Karnasuta, Hathairat Savadsuk, Sirinan Madnote, Dutsadee Inthawong, Somsak Chantakulkij, Surawach Rittiroongrad, Sorachai Nitayaphan, Punnee Pitisuttithum, Prasert Thongcharoen, Vinai Siriyanon, Charla A. Andrews, Susan W. Barnett, James Tartaglia, Faruk Sinangil, Donald P. Francis, Merlin L. Robb, Nelson L. Michael, Viseth Ngauy, Mark S. De Souza, Robert M. Paris, Jean Louis Excler, Jerome H. Kim, Robert J. O'Connell
Published 2018

IgG Antibody Responses to Recombinant gp120 Proteins, gp70V1/V2 Scaffolds, and a CyclicV2 Peptide in Thai Phase I/II Vaccine Trials Using Different Vaccine Regimens

by Nicos Karasavvas, Chitraporn Karnasuta, Hathairat Savadsuk, Sirinan Madnote, Dutsadee Inthawong, Somsak Chantakulkij, Surawach Rittiroongrad, Sorachai Nitayaphan, Punnee Pitisuttithum, Prasert Thongcharoen, Vinai Siriyanon, Charla A. Andrews, Susan W. Barnett, James Tartaglia, Faruk Sinangil, Donald P. Francis, Merlin L. Robb, Nelson L. Michael, Viseth Ngauy, Mark S. De Souza, Robert M. Paris, Jean Louis Excler, Jerome H. Kim, Robert J. O'Connell
Published 2018

IgG Antibody Responses to Recombinant gp120 Proteins, gp70V1/V2 Scaffolds, and a CyclicV2 Peptide in Thai Phase I/II Vaccine Trials Using Different Vaccine Regimens

by Nicos Karasavvas, Chitraporn Karnasuta, Hathairat Savadsuk, Sirinan Madnote, Dutsadee Inthawong, Somsak Chantakulkij, Surawach Rittiroongrad, Sorachai Nitayaphan, Punnee Pitisuttithum, Prasert Thongcharoen, Vinai Siriyanon, Charla A. Andrews, Susan W. Barnett, James Tartaglia, Faruk Sinangil, Donald P. Francis, Merlin L. Robb, Nelson L. Michael, Viseth Ngauy, Mark S. De Souza, Robert M. Paris, Jean Louis Excler, Jerome H. Kim, Robert J. O'Connell
Published 2018

Antibody to HSV gD peptide induced by vaccination does not protect against HSV-2 infection in HSV-2 seronegative women

by Peter B. Gilbert, Jean Louis Excler, Georgia D. Tomaras, Lindsay N. Carpp, Barton F. Haynes, Hua Xin Liao, David C. Montefiori, Supachai Rerks-Ngarm, Punnee Pitisuttithum, Sorachai Nitayaphan, Jaranit Kaewkungwal, Gustavo H. Kijak, Sodsai Tovanabutra, Donald P. Francis, Carter Lee, Faruk Sinangil, Phillip W. Berman, Nakorn Premsri, Prayura Kunasol, Robert J. O'Connell, Nelson L. Michael, Merlin L. Robb, Rhoda Morrow, Lawrence Corey, Jerome H. Kim
Published 2018

Plasma IgG to Linear Epitopes in the V2 and V3 Regions of HIV-1 gp120 Correlate with a Reduced Risk of Infection in the RV144 Vaccine Efficacy Trial

by Raphael Gottardo, Robert T. Bailer, Bette T. Korber, S. Gnanakaran, Joshua Phillips, Xiaoying Shen, Georgia D. Tomaras, Ellen Turk, Gregory Imholte, Larry Eckler, Holger Wenschuh, Johannes Zerweck, Kelli Greene, Hongmei Gao, Phillip W. Berman, Donald Francis, Faruk Sinangil, Carter Lee, Sorachai Nitayaphan, Supachai Rerks-Ngarm, Jaranit Kaewkungwal, Punnee Pitisuttithum, James Tartaglia, Merlin L. Robb, Nelson L. Michael, Jerome H. Kim, Susan Zolla-Pazner, Barton F. Haynes, John R. Mascola, Steve Self, Peter Gilbert, David C. Montefiori
Published 2018

Boosting with AIDSvax B/E enhances Env constant region 1 and 2 antibody-dependent cellular cytotoxicity breadth and potency

by David Easterhoff, Justin Pollara, Kan Luo, William D. Tolbert, Brianna Young, Dieter Mielke, Shalini Jha, Robert J. O’Connell, Sandhya Vasan, Jerome Kim, Nelson L. Michael, Jean Louis Excler, Merlin L. Robb, Supachai Rerks-Ngarm, Jaranit Kaewkungwal, Punnee Pitisuttithum, Sorachai Nitayaphan, Faruk Sinangil, James Tartaglia, Sanjay Phogat, Thomas B. Kepler, S. Munir Alam, Kevin Wiehe, Kevin O. Saunders, David C. Montefiori, Georgia D. Tomaras, M. Anthony Moody, Marzena Pazgier, Barton F. Haynes, Guido Ferrari
Published 2020

Antibody light-chain-restricted recognition of the site of immune pressure in the RV144 HIV-1 vaccine trial is phylogenetically conserved

by Kevin Wiehe, David Easterhoff, Kan Luo, Nathan I. Nicely, Todd Bradley, Frederick H. Jaeger, S. Moses Dennison, Ruijun Zhang, Krissey E. Lloyd, Christina Stolarchuk, Robert Parks, Laura L. Sutherland, Richard M. Scearce, Lynn Morris, Jaranit Kaewkungwal, Sorachai Nitayaphan, Punnee Pitisuttithum, Supachai Rerks-Ngarm, Faruk Sinangil, Sanjay Phogat, Nelson L. Michael, Jerome H. Kim, Garnett Kelsoe, David C. Montefiori, Georgia D. Tomaras, Mattia Bonsignori, Sampa Santra, Thomas B. Kepler, S. Munir Alam, M. Anthony Moody, Hua Xin Liao, Barton F. Haynes
Published 2018

Boosting of HIV envelope CD4 binding site antibodies with long variable heavy third complementarity determining region in the randomized double blind RV305 HIV-1 vaccine trial

by David Easterhoff, M. Anthony Moody, Daniela Fera, Hao Cheng, Margaret Ackerman, Kevin Wiehe, Kevin O. Saunders, Justin Pollara, Nathan Vandergrift, Rob Parks, Jerome Kim, Nelson L. Michael, Robert J. O’Connell, Jean Louis Excler, Merlin L. Robb, Sandhya Vasan, Supachai Rerks-Ngarm, Jaranit Kaewkungwal, Punnee Pitisuttithum, Sorachai Nitayaphan, Faruk Sinangil, James Tartaglia, Sanjay Phogat, Thomas B. Kepler, S. Munir Alam, Hua Xin Liao, Guido Ferrari, Michael S. Seaman, David C. Montefiori, Georgia D. Tomaras, Stephen C. Harrison, Barton F. Haynes
Published 2018

Antigenicity and immunogenicity of RV144 vaccine AIDSVAX clade E envelope immunogen is enhanced by a gp120 N-terminal deletion

by Munir S. Alam, Hua Xin Liao, Georgia D. Tomaras, Mattia Bonsignori, Chun Yen Tsao, Kwan Ki Hwang, Haiyan Chen, E. Lloyd Krissey E., Cindy Bowman, Laura Sutherland, Thomas L. Jeffries, Daniel M. Kozink, Shelley Stewart, Kara Anasti, Frederick H. Jaeger, Robert Parks, Nicole L. Yates, Glenn R. Overman, Faruk Sinangil, Phillip W. Berman, Punnee Pitisuttithum, Jaranit Kaewkungwal, Sorachai Nitayaphan, Nicos Karasavva, Supachai Rerks-Ngarm, Jerome H. Kim, Nelson L. Michael, Susan Zolla-Pazner, Sampa Santra, Norman L. Letvin, Stephen C. Harrison, Barton F. Haynes
Published 2018

Vaccine-induced Env V1-V2 IgG3 correlates with lower HIV-1 infection risk and declines soon after vaccination

by Nicole L. Yates, Hua Xin Liao, Youyi Fong, Allan DeCamp, Nathan A. Vandergrift, William T. Williams, S. Munir Alam, Guido Ferrari, Zhi Yong Yang, Kelly E. Seaton, Phillip W. Berman, Michael D. Alpert, David T. Evans, Robert J. O'Connell, Donald Francis, Faruk Sinangil, Carter Lee, Sorachai Nitayaphan, Supachai Rerks-Ngarm, Jaranit Kaewkungwal, Punnee Pitisuttithum, James Tartaglia, Abraham Pinter, Susan Zolla-Pazner, Peter B. Gilbert, Gary J. Nabel, Nelson L. Michael, Jerome H. Kim, David C. Montefiori, Barton F. Haynes, Georgia D. Tomaras
Published 2018

Magnitude and breadth of the neutralizing antibody response in the RV144 and Vax003 HIV-1 vaccine efficacy trials

by David C. Montefiori, Chitraporn Karnasuta, Ying Huang, Hasan Ahmed, Peter Gilbert, Mark S. De Souza, Robert McLinden, Sodsai Tovanabutra, Agnes Laurence-Chenine, Eric Sanders-Buell, M. Anthony Moody, Mattia Bonsignori, Christina Ochsenbauer, John Kappes, Haili Tang, Kelli Greene, Hongmei Gao, Celia C. Labranche, Charla Andrews, Victoria R. Polonis, Supachai Rerks-Ngarm, Punnee Pitisuttithum, Sorachai Nitayaphan, Jaranit Kaewkungwal, Steve G. Self, Phillip W. Berman, Donald Francis, Faruk Sinangil, Carter Lee, Jim Tartaglia, Merlin L. Robb, Barton F. Haynes, Nelson L. Michael, Jerome H. Kim
Published 2018

The thai phase III HIV type 1 vaccine trial (RV144) regimen induces antibodies that target conserved regions within the V2 loop of gp120

by Nicos Karasavvas, Erik Billings, Mangala Rao, Constance Williams, Susan Zolla-Pazner, Robert T. Bailer, Richard A. Koup, Sirinan Madnote, Duangnapa Arworn, Xiaoying Shen, Georgia D. Tomaras, Jeffrey R. Currier, Mike Jiang, Craig Magaret, Charla Andrews, Raphael Gottardo, Peter Gilbert, Timothy J. Cardozo, Supachai Rerks-Ngarm, Sorachai Nitayaphan, Punnee Pitisuttithum, Jaranit Kaewkungwal, Robert Paris, Kelli Greene, Hongmei Gao, Sanjay Gurunathan, Jim Tartaglia, Faruk Sinangil, Bette T. Korber, David C. Montefiori, John R. Mascola, Merlin L. Robb, Barton F. Haynes, Viseth Ngauy, Nelson L. Michael, Jerome H. Kim, Mark S. De Souza
Published 2018

Vaccine Induction of Antibodies against a Structurally Heterogeneous Site of Immune Pressure within HIV-1 Envelope Protein Variable Regions 1 and 2

by Hua Xin Liao, Mattia Bonsignori, S. Munir Alam, Jason S. McLellan, Georgia D. Tomaras, M. Anthony Moody, Daniel M. Kozink, Kwan Ki Hwang, Xi Chen, Chun Yen Tsao, Pinghuang Liu, Xiaozhi Lu, Robert J. Parks, David C. Montefiori, Guido Ferrari, Justin Pollara, Mangala Rao, Kristina K. Peachman, Sampa Santra, Norman L. Letvin, Nicos Karasavvas, Zhi Yong Yang, Kaifan Dai, Marie Pancera, Jason Gorman, Kevin Wiehe, Nathan I. Nicely, Supachai Rerks-Ngarm, Sorachai Nitayaphan, Jaranit Kaewkungwal, Punnee Pitisuttithum, James Tartaglia, Faruk Sinangil, Jerome H. Kim, Nelson L. Michael, Thomas B. Kepler, Peter D. Kwong, John R. Mascola, Gary J. Nabel, Abraham Pinter, Susan Zolla-Pazner, Barton F. Haynes
Published 2018

HIV vaccine delayed boosting increases Env variable region 2–specific antibody effector functions

by David Easterhoff, Justin Pollara, Kan Luo, Benjamin Janus, Neelakshi Gohain, La Tonya D. Williams, Matthew Zirui Tay, Anthony Monroe, Kristina Peachman, Misook Choe, Susie Min, Paolo Lusso, Peng Zhang, Eden P. Go, Heather Desaire, Mattia Bonsignori, Kwan Ki Hwang, Charles Beck, Matina Kakalis, Robert J. O’Connell, Sandhya Vasan, Jerome H. Kim, Nelson L. Michael, Jean Louis Excler, Merlin L. Robb, Supachai Rerks-Ngarm, Jaranit Kaewkungwal, Punnee Pitisuttithum, Sorachai Nitayaphan, Faruk Sinangil, James Tartaglia, Sanjay Phogat, Kevin Wiehe, Kevin O. Saunders, David C. Montefiori, Georgia D. Tomaras, M. Anthony Moody, James Arthos, Mangala Rao, M. Gordon Joyce, Gilad Ofek, Guido Ferrari, Barton F. Haynes
Published 2020

Late boosting of the RV144 regimen with AIDSVAX B/E and ALVAC-HIV in HIV-uninfected Thai volunteers: a double-blind, randomised controlled trial

by Punnee Pitisuttithum, Sorachai Nitayaphan, Suwat Chariyalertsak, Jaranit Kaewkungwal, Peter Dawson, Jittima Dhitavat, Benjaluck Phonrat, Siriwat Akapirat, Nicos Karasavvas, Lindsay Wieczorek, Victoria Polonis, Michael A. Eller, Poonam Pegu, Dohoon Kim, Alexandra Schuetz, Surat Jongrakthaitae, Yingjun Zhou, Faruk Sinangil, Sanjay Phogat, Carlos A. Diazgranados, James Tartaglia, Elizabeth Heger, Kirsten Smith, Nelson L. Michael, Jean Louis Excler, Merlin L. Robb, Jerome H. Kim, Robert J. O'Connell, Sandhya Vasan, Arom Pitisuthitham, Yupa Sabmee, Narongrid Sirisopana, Chirapa Eamsila, Prapaporn Savaraj, Wanlaya Labwech, Siriluck Teerachia, Nuntisa Chotirosniramit, Taweewat Supindham, Boonlure Pruenglampoo, Patcharaphan Sugandhavesa, Natthapol Kosashunhanan, Oranitcha Kaewthip, Piyathida Sroysuwan, Pawinee Jarujareet, Silvia Ratto-Kim, Sebastian Molnar, Jesse Schoen, Nampueng Churikanont, Saowanit Getchalarat, Nongluck Sangnoi, Bessara Nuntapinit, Anant Phramtong, Pornsuk V. Grandin, Sirinan Madnote, Surawach Rittiroongrad, Boot Kaewboon, Rapee Trichavaroj, Jiraporn Puangkaew, Somsak Chantakulkij, Phiromrat Rakyat, Pornchanok Panjapornsuk, Nipattra Tragonlugsana, Weerawan Chuenarom, Mark de Souza, Viseth Ngauy, Nittaya Phanuphak, Nitiya Chomchey, Puttachard Saengtawan, Nipat Teeratakulpisarn, Rungsun Rerknimitr, Eugene Kroon, Carter A. Lee, Suchada Chinaworapong
Published 2020

Late boosting of the RV144 regimen with AIDSVAX B/E and ALVAC-HIV in HIV-uninfected Thai volunteers: a double-blind, randomised controlled trial

by Punnee Pitisuttithum, Sorachai Nitayaphan, Suwat Chariyalertsak, Jaranit Kaewkungwal, Peter Dawson, Jittima Dhitavat, Benjaluck Phonrat, Siriwat Akapirat, Nicos Karasavvas, Lindsay Wieczorek, Victoria Polonis, Michael A. Eller, Poonam Pegu, Dohoon Kim, Alexandra Schuetz, Surat Jongrakthaitae, Yingjun Zhou, Faruk Sinangil, Sanjay Phogat, Carlos A. Diazgranados, James Tartaglia, Elizabeth Heger, Kirsten Smith, Nelson L. Michael, Jean Louis Excler, Merlin L. Robb, Jerome H. Kim, Robert J. O'Connell, Sandhya Vasan, Arom Pitisuthitham, Yupa Sabmee, Narongrid Sirisopana, Chirapa Eamsila, Prapaporn Savaraj, Wanlaya Labwech, Siriluck Teerachia, Nuntisa Chotirosniramit, Taweewat Supindham, Boonlure Pruenglampoo, Patcharaphan Sugandhavesa, Natthapol Kosashunhanan, Oranitcha Kaewthip, Piyathida Sroysuwan, Pawinee Jarujareet, Silvia Ratto-Kim, Sebastian Molnar, Jesse Schoen, Nampueng Churikanont, Saowanit Getchalarat, Nongluck Sangnoi, Bessara Nuntapinit, Anant Phramtong, Pornsuk V. Grandin, Sirinan Madnote, Surawach Rittiroongrad, Boot Kaewboon, Rapee Trichavaroj, Jiraporn Puangkaew, Somsak Chantakulkij, Phiromrat Rakyat, Pornchanok Panjapornsuk, Nipattra Tragonlugsana, Weerawan Chuenarom, Mark de Souza, Viseth Ngauy, Nittaya Phanuphak, Nitiya Chomchey, Puttachard Saengtawan, Nipat Teeratakulpisarn, Rungsun Rerknimitr, Eugene Kroon, Carter A. Lee, Suchada Chinaworapong
Published 2020