A facile and novel synthesis of N2-, C6-substituted pyrazolo[3,4- d ]pyrimidine-4 carboxylate derivatives as adenosine receptor antagonists

by Venkatesan G., Paira P., Cheong S.L., Federico S., Klotz K.N., Spalluto G., Pastorin G.
Published 2016

Exploring the directionality of 5-substitutions in a new series of 5-alkylaminopyrazolo[4,3-e]1,2,4-triazolo[1,5-c]pyrimidine as a strategy to design novel human A3 adenosine recep...

by Federico, S., Ciancetta, A., Sabbadin, D., Paoletta, S., Pastorin, G., Cacciari, B., Klotz, K.N., Moro, S., Spalluto, G.
Published 2014

Discovery of simplified N2-substituted pyrazolo[3,4-d]pyrimidine derivatives as novel adenosine receptor antagonists: Efficient synthetic approaches, biological evaluations and mol...

by Venkatesan, G., Paira, P., Cheong, S.L., Vamsikrishna, K., Federico, S., Klotz, K.-N., Spalluto, G., Pastorin, G.
Published 2014

The significance of 2-furyl ring substitution with a 2-(para -substituted) aryl group in a new series of pyrazolo-triazolo-pyrimidines as potent and highly selective hA3 adenosine...

by Cheong, S.L., Dolzhenko, A., Kachler, S., Paoletta, S., Federico, S., Cacciari, B., Dolzhenko, A., Klotz, K.-N., Moro, S., Spalluto, G., Pastorin, G.
Published 2014

Organoruthenium antagonists of human A3 adenosine receptors

by Paira, P., Chow, M.J., Venkatesan, G., Kosaraju, V.K., Cheong, S.L., Klotz, K.-N., Ang, W.H., Pastorin, G.
Published 2014

Combining selectivity and affinity predictions using an integrated Support Vector Machine (SVM) approach: An alternative tool to discriminate between the human adenosine A2A and A3...

by Michielan, L., Bolcato, C., Federico, S., Cacciari, B., Bacilieri, M., Klotz, K.-N., Kachler, S., Pastorin, G., Cardin, R., Sperduti, A., Spalluto, G., Moro, S.
Published 2014

Synthesis and pharmacological characterization of a new series of 5,7-disubstituted-[1,2,4]triazolo[1,5-a][1,3,5]triazine derivatives as adenosine receptor antagonists: A prelimina...

by Pastorin, G., Federico, S., Paoletta, S., Corradino, M., Cateni, F., Cacciari, B., Klotz, K.-N., Gao, Z.-G., Jacobson, K.A., Spalluto, G., Moro, S.
Published 2014

Does the combination of optimal substitutions at the C 2-, N 5- and N 8-positions of the pyrazolo-triazolo-pyrimidine scaffold guarantee selective modulation of the human A 3 adeno...

by Cheong, S.L., Dolzhenko, A.V., Paoletta, S., Lee, E.P.R., Kachler, S., Federico, S., Klotz, K.-N., Dolzhenko, A.V., Spalluto, G., Moro, S., Pastorin, G.
Published 2014

Design, synthesis and evaluation of new indolylpyrimidylpiperazines for gastrointestinal cancer therapy

by Tan, A., Babak, M.V., Venkatesan, G., Lim, C., Klotz, K.-N., Herr, D.R., Cheong, S.L., Federico, S., Spalluto, G., Ong, W.-Y., Chen, Y.Z., Loo, J.S.E., Pastori, G.
Published 2021

Discovery of indolylpiperazinylpyrimidines with dual-target profiles at adenosine A2A and dopamine D2 receptors for Parkinson’s disease treatment

by Shao Y.-M., Ma X., Paira P., Tan A., Herr D.R., Lim K.L., Ng C.H., Venkatesan G., Klotz K.-N., Federico S., Spalluto G., Cheong S.L., Chen Y.Z., Pastorin G.
Published 2018