The amyloid precursor protein: Beyond amyloid

by Zheng H., Koo E.H.
Published 2018

Biology and pathophysiology of the amyloid precursor protein

by Zheng H., Koo E.H.
Published 2018

Inter-dependent mechanisms behind cognitive dysfunction, vascular biology and Alzheimer’s dementia in down syndrome: Multi-faceted roles of APP

by Nizetic, D, Chen, C.L, Hong, W, Koo, E.H
Published 2020

Modulation of Aβ42 in vivo by γ-secretase modulator in primates and humans

by Ling, I.-F, Golde, T.E, Galasko, D.R, Koo, E.H
Published 2020

γ-Secretase Modulators and APH1 Isoforms Modulate γ-Secretase Cleavage but Not Position of ε-Cleavage of the Amyloid Precursor Protein (APP)

by Lessard C.B., Cottrell B.A., Maruyama H., Suresh S., Golde T.E., Koo E.H.
Published 2018

Caspase Activation and Caspase-Mediated Cleavage of APP Is Associated with Amyloid ?-Protein-Induced Synapse Loss in Alzheimer's Disease

by Park, G., Nhan, H.S., Tyan, S.-H., Kawakatsu, Y., Zhang, C., Navarro, M., Koo, E.H.
Published 2021

Specific disruption of hippocampal mossy fiber synapses in a mouse model of familial Alzheimer's disease

by Wilke S.A., Raam T., Antonios J.K., Bushong E.A., Koo E.H., Ellisman M.H., Ghosh A.
Published 2018

Chronic administration of R-flurbiprofen attenuates learning impairments in transgenic amyloid precursor protein mice

by Kukar T., Prescott S., Eriksen J.L., Holloway V., Murphy M.P., Koo E.H., Golde T.E., Nicolle M.M.
Published 2018

Independent Relationship between Amyloid Precursor Protein (APP) Dimerization and γ-Secretase Processivity

by Jung J.I., Premraj S., Cruz P.E., Ladd T.B., Kwak Y., Koo E.H., Felsenstein K.M., Golde T.E., Ran Y.
Published 2018

Prevalence of cognitive impairment in Chinese: Epidemiology of Dementia in Singapore study

by Hilal, S., Ikram, M.K., Saini, M., Tan, C.S., Catindig, J.A., Dong, Y.H., Lim, L.B.S., Ting, E.Y.S., Koo, E.H., Cheung, C.Y.L., Qiu, A., Wong, T.Y., Chen, C.L.-H., Venketasubramanian, N.
Published 2014

Cholestenoic acid, an endogenous cholesterol metabolite, is a potent ?-secretase modulator

by Jung J.I., Price A.R., Ladd T.B., Ran Y., Park H.-J., Ceballos-Diaz C., Smithson L.A., Hochhaus G., Tang Y., Akula R., Ba S., Koo E.H., Shapiro G., Felsenstein K.M., Golde T.E.
Published 2018

APP upregulation contributes to retinal ganglion cell degeneration via JNK3

by Liu C., Zhang C.-W., Zhou Y., Wong W.Q., Lee L.C., Ong W.Y., Yoon S.O., Hong W., Fu X.-Y., Soong T.W., Koo E.H., Stanton L.W., Lim K.-L., Xiao Z.-C., Dawe G.S.
Published 2018

Alzheimer's disease risk polymorphisms regulate gene expression in the ZCWPW1 and the CELF1 loci

by Karch C.M., Ezerskiy L.A., Bertelsen S., Goate A.M., Albert M.S., Albin R.L., Apostolova L.G., Arnold S.E., Baldwin C.T., Barber R., Barmada M.M., Barnes L.L., Beach T.G., Beecham G.W., Beekly D., Bennett D.A., Bigio E.H., Bird T.D., Blacker D., Boeve B.F., Bowen J.D., Boxer A., Burke J.R., Buxbaum J.D., Cairns N.J., Cantwell L.B., Cao C., Carlson C.S., Carney R.M., Carrasquillo M.M., Carroll S.L., Chui H.C., Clark D.G., Corneveaux J., Crane P.K., Cribbs D.H., Crocco E.A., Cruchaga C., De Jager P.L., DeCarli C., DeKosky S.T., Demirci F.Y., Dick M., Dickson D.W., Duara R., Ertekin-Taner N., Evans D., Faber K.M., Fallon K.B., Farlow M.R., Ferris S., Foroud T.M., Frosch M.P., Galasko D.R., Ganguli M., Gearing M., Geschwind D.H., Ghetti B., Gilbert J.R., Gilman S., Glass J.D., Graff-Radford N.R., Green R.C., Growdon J.H., Hakonarson H., Hamilton-Nelson K.L., Hamilton R.L., Hardy J., Harrell L.E., Head E., Honig L.S., Huentelman M.J., Hulette C.M., Hyman B.T., Jarvik G.P., Jicha G.A., Jin L.-W., Kamboh M.I., Karydas A., Kauwe J.S.K., Kaye J.A., Kim R., Koo E.H., Kowall N.W., Kramer J.H., Kramer P., Kukull W.A., LaFerla F.M., Lah J.J., Larson E.B., Leverenz J.B., Levey A.I., Li G., Lin C.-F., Lieberman A.P., Lopez O.L., Lunetta K.L., Lyketsos C.G., Mack W.J., Marson D.C., Martin E.R., Martiniuk F., Mash D.C., Masliah E., McCormick W.C., McCurry S.M., McDavid A.N., McKee A.C., Mesulam M., Miller B.L., Miller C.A., Miller J.W., Montine T.J., Morris J.C., Murrell J.R., Myers A.J., Naj A.C., Olichney J.M., Pankratz V.S., Parisi J.E., Peskind E., Petersen R.C., Pierce A., Poon W.W., Potter H., Quinn J.F., Raj A., Rajbhandary R.A., Raskind M., Reiman E.M., Reisberg B., Reitz C., Ringman J.M., Roberson E.D., Rogaeva E., Rosen H.J., Rosenberg R.N., Sano M., Saykin A.J., Schneider J.A., Schneider L.S., Seeley W.W., Smith A.G., Sonnen J.A., Spina S., Stern R.A., Tanzi R.E., Trojanowski J.Q., Troncoso J.C., Tsuang D.W., Valladares O., Van Deerlin V.M., Van Eldik L.J., Vardarajan B.N., Vinters H.V., Vonsattel J.P., Weintraub S., Welsh-Bohmer K.A., Williamson J., Woltjer R.L., Wright C.B., Younkin S.G., Yu C.-E., Yu L.
Published 2018