Modulation of Aβ42 in vivo by γ-secretase modulator in primates and humans

10.1186/s13195-015-0137-y

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Bibliographic Details
Main Authors:	Ling, I.-F, Golde, T.E, Galasko, D.R, Koo, E.H
Other Authors:	MEDICINE
Format:	Article
Published:	2020
Subjects:	amyloid beta protein amyloid precursor protein gamma secretase gamma secretase inhibitor ibuprofen indometacin nonsteroid antiinflammatory agent placebo sulindac sulfide amyloid beta protein[1-40] amyloid beta-protein (1-42) APP protein, human peptide fragment secretase Alzheimer disease animal experiment Article cerebrospinal fluid CHO cell line controlled study degenerative disease drug blood level electrospray female gene mutation human in vitro study in vivo study Macaca fascicularis neuromodulation nonhuman nuclear magnetic resonance primate priority journal protein cleavage risk reduction single drug dose thin layer chromatography adult animal blood Cricetulus dose response genetics male metabolism randomization time factor treatment outcome young adult Adult Amyloid beta-Peptides Amyloid beta-Protein Precursor Amyloid Precursor Protein Secretases Animals Anti-Inflammatory Agents, Non-Steroidal CHO Cells Dose-Response Relationship, Drug Female Humans Ibuprofen Male Peptide Fragments Random Allocation Time Factors Treatment Outcome Young Adult
Online Access:	https://scholarbank.nus.edu.sg/handle/10635/180902
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Institution:	National University of Singapore

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