Modulation of Aβ42 in vivo by γ-secretase modulator in primates and humans

• Main Authors: Ling, I.-F, Golde, T.E, Galasko, D.R, Koo, E.H
• Other Authors: MEDICINE
• Format: Article
• Published: 2020
• Subjects: amyloid beta protein; amyloid precursor protein; gamma secretase; gamma secretase inhibitor; ibuprofen; indometacin; nonsteroid antiinflammatory agent; placebo; sulindac sulfide; amyloid beta protein[1-40]; amyloid beta-protein (1-42); APP protein, human; peptide fragment; secretase; Alzheimer disease; animal experiment; Article; cerebrospinal fluid; CHO cell line; controlled study; degenerative disease; drug blood level; electrospray; female; gene mutation; human; in vitro study; in vivo study; Macaca fascicularis; neuromodulation; nonhuman; nuclear magnetic resonance; primate; priority journal; protein cleavage; risk reduction; single drug dose; thin layer chromatography; adult; animal; blood; Cricetulus; dose response; genetics; male; metabolism; randomization; time factor; treatment outcome; young adult; Adult; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Animals; Anti-Inflammatory Agents, Non-Steroidal; CHO Cells; Dose-Response Relationship, Drug; Female; Humans; Ibuprofen; Male; Peptide Fragments; Random Allocation; Time Factors; Treatment Outcome; Young Adult
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/180902
• Institution: National University of Singapore

10.1186/s13195-015-0137-y