Stability analysis of the ODE model representation of amyloidogenic processing in Alzheimer's disease in the presence of SORLA

• Main Authors: Alcantara, Jan Harold Mercado, Lao, Angelyn R., Ruivivar, Leonor A.
• Format: text
• Published: Animo Repository 2016
• Subjects: Amyloid beta-protein precursor—Mathematical models; Alzheimer's disease; Proteins—Stability; Mathematics
• Online Access: https://animorepository.dlsu.edu.ph/faculty_research/353; https://animorepository.dlsu.edu.ph/context/faculty_research/article/1352/type/native/viewcontent
• Institution: De La Salle University

The proteolytic breakdown of the amyloid precursor protein (APP) by secretases is a complex cellular process that results in the formation of neurotoxic Aβ peptides, causative of neurodegeneration in Alzheimer's disease (AD). Processing involves monomeric and dimeric forms of APP that are trans...