Multi-compartmental modeling of SORLA’s influence on amyloidogenic processing in Alzheimer’s disease

• Main Authors: Lao, Angelyn R., Schmidt, Vanessa, Schmitz, Yvonne, Willnow, Thomas E., Wolkenhauer, Olaf
• Format: text
• Published: Animo Repository 2012
• Subjects: Amyloid beta-protein precursor—Mathematical models; Alzheimer's disease; Mathematics
• Online Access: https://animorepository.dlsu.edu.ph/faculty_research/7439
• Institution: De La Salle University

Proteolytic breakdown of the amyloid precursor protein (APP) by secretases is a complex cellular process that results in formation of neurotoxic Aβ peptides, causative of neurodegeneration in Alzheimer’s disease (AD). Processing involves monomeric and dimeric forms of APP that traffic through distin...