Modulation of Aβ42 in vivo by γ-secretase modulator in primates and humans
10.1186/s13195-015-0137-y
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sg-nus-scholar.10635-1809022024-04-18T03:08:37Z Modulation of Aβ42 in vivo by γ-secretase modulator in primates and humans Ling, I.-F Golde, T.E Galasko, D.R Koo, E.H MEDICINE amyloid beta protein amyloid precursor protein gamma secretase gamma secretase inhibitor ibuprofen indometacin nonsteroid antiinflammatory agent placebo sulindac sulfide amyloid beta protein amyloid beta protein[1-40] amyloid beta-protein (1-42) amyloid precursor protein APP protein, human ibuprofen nonsteroid antiinflammatory agent peptide fragment secretase Alzheimer disease animal experiment Article cerebrospinal fluid CHO cell line controlled study degenerative disease drug blood level electrospray female gene mutation human in vitro study in vivo study Macaca fascicularis neuromodulation nonhuman nuclear magnetic resonance primate priority journal protein cleavage risk reduction single drug dose thin layer chromatography adult animal blood Cricetulus dose response genetics male metabolism randomization time factor treatment outcome young adult Adult Amyloid beta-Peptides Amyloid beta-Protein Precursor Amyloid Precursor Protein Secretases Animals Anti-Inflammatory Agents, Non-Steroidal CHO Cells Cricetulus Dose-Response Relationship, Drug Female Humans Ibuprofen Macaca fascicularis Male Peptide Fragments Random Allocation Time Factors Treatment Outcome Young Adult 10.1186/s13195-015-0137-y Alzheimer's Research and Therapy 7 1 55 2020-10-27T05:38:33Z 2020-10-27T05:38:33Z 2015 Article Ling, I.-F, Golde, T.E, Galasko, D.R, Koo, E.H (2015). Modulation of Aβ42 in vivo by γ-secretase modulator in primates and humans. Alzheimer's Research and Therapy 7 (1) : 55. ScholarBank@NUS Repository. https://doi.org/10.1186/s13195-015-0137-y 17589193 https://scholarbank.nus.edu.sg/handle/10635/180902 Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ Unpaywall 20201031 |
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amyloid beta protein amyloid precursor protein gamma secretase gamma secretase inhibitor ibuprofen indometacin nonsteroid antiinflammatory agent placebo sulindac sulfide amyloid beta protein amyloid beta protein[1-40] amyloid beta-protein (1-42) amyloid precursor protein APP protein, human ibuprofen nonsteroid antiinflammatory agent peptide fragment secretase Alzheimer disease animal experiment Article cerebrospinal fluid CHO cell line controlled study degenerative disease drug blood level electrospray female gene mutation human in vitro study in vivo study Macaca fascicularis neuromodulation nonhuman nuclear magnetic resonance primate priority journal protein cleavage risk reduction single drug dose thin layer chromatography adult animal blood Cricetulus dose response genetics male metabolism randomization time factor treatment outcome young adult Adult Amyloid beta-Peptides Amyloid beta-Protein Precursor Amyloid Precursor Protein Secretases Animals Anti-Inflammatory Agents, Non-Steroidal CHO Cells Cricetulus Dose-Response Relationship, Drug Female Humans Ibuprofen Macaca fascicularis Male Peptide Fragments Random Allocation Time Factors Treatment Outcome Young Adult |
| spellingShingle |
amyloid beta protein amyloid precursor protein gamma secretase gamma secretase inhibitor ibuprofen indometacin nonsteroid antiinflammatory agent placebo sulindac sulfide amyloid beta protein amyloid beta protein[1-40] amyloid beta-protein (1-42) amyloid precursor protein APP protein, human ibuprofen nonsteroid antiinflammatory agent peptide fragment secretase Alzheimer disease animal experiment Article cerebrospinal fluid CHO cell line controlled study degenerative disease drug blood level electrospray female gene mutation human in vitro study in vivo study Macaca fascicularis neuromodulation nonhuman nuclear magnetic resonance primate priority journal protein cleavage risk reduction single drug dose thin layer chromatography adult animal blood Cricetulus dose response genetics male metabolism randomization time factor treatment outcome young adult Adult Amyloid beta-Peptides Amyloid beta-Protein Precursor Amyloid Precursor Protein Secretases Animals Anti-Inflammatory Agents, Non-Steroidal CHO Cells Cricetulus Dose-Response Relationship, Drug Female Humans Ibuprofen Macaca fascicularis Male Peptide Fragments Random Allocation Time Factors Treatment Outcome Young Adult Ling, I.-F Golde, T.E Galasko, D.R Koo, E.H Modulation of Aβ42 in vivo by γ-secretase modulator in primates and humans |
| description |
10.1186/s13195-015-0137-y |
| author2 |
MEDICINE |
| author_facet |
MEDICINE Ling, I.-F Golde, T.E Galasko, D.R Koo, E.H |
| format |
Article |
| author |
Ling, I.-F Golde, T.E Galasko, D.R Koo, E.H |
| author_sort |
Ling, I.-F |
| title |
Modulation of Aβ42 in vivo by γ-secretase modulator in primates and humans |
| title_short |
Modulation of Aβ42 in vivo by γ-secretase modulator in primates and humans |
| title_full |
Modulation of Aβ42 in vivo by γ-secretase modulator in primates and humans |
| title_fullStr |
Modulation of Aβ42 in vivo by γ-secretase modulator in primates and humans |
| title_full_unstemmed |
Modulation of Aβ42 in vivo by γ-secretase modulator in primates and humans |
| title_sort |
modulation of aβ42 in vivo by γ-secretase modulator in primates and humans |
| publishDate |
2020 |
| url |
https://scholarbank.nus.edu.sg/handle/10635/180902 |
| _version_ |
1800914614388523008 |