Virus infection drives IL-2 antibody complexes into pro-inflammatory agonists in mice

by Lee, W.W.L, Teo, T.-H, Lum, F.-M, Andiappan, A.K, Amrun, S.N, Rénia, L, Rötzschke, O, Ng, L.F.P
Published 2020

Co-infection with Chikungunya virus alters trafficking of pathogenic CD8+ T cells into the brain and prevents Plasmodium-induced neuropathology

by Teo, T.-H, Howland, S.W, Claser, C, Gun, S.Y, Poh, C.M, Lee, W.W.L, Lum, F.-M, Ng, L.F.P, Rénia, L
Published 2020

Antibody-mediated enhancement aggravates chikungunya virus infection and disease severity

by Lum, F.-M, Couderc, T, Chia, B.-S, Ong, R.-Y, Her, Z, Chow, A, Leo, Y.-S, Kam, Y.-W, Rénia, L, Lecuit, M, Ng, L.F.P
Published 2020

Type i interferon shapes the quantity and quality of the anti-zika virus antibody response

by Yi-Pin Lee, C., Carissimo, G., Chen, Z., Lum, F.-M., Abu Bakar, F., Rajarethinam, R., Teo, T.-H., Torres-Ruesta, A., Renia, L., Ng, L.F.P.
Published 2021

Paradoxical effect of chloroquine treatment in enhancing chikungunya virus infection

by Roques, P, Thiberville, S.-D, Dupuis-Maguiraga, L, Lum, F.-M, Labadie, K, Martinon, F, Gras, G, Lebon, P, Ng, L.F.P, de Lamballerie, X, Le Grand, R
Published 2020

Viperin controls chikungunya virus-specific pathogenic T cell IFN? Th1 stimulation in mice

by Carissimo, G., Teo, T.-H., Chan, Y.-H., Lee, C.Y.-P., Lee, B., Torres-Ruesta, A., Tan, J.J.L., Chua, T.-K., Fong, S.-W., Lum, F.-M., Ng, L.F.P.
Published 2021

Novel differential linear B-cell epitopes to identify Zika and dengue virus infections in patients

by Amrun, S.N., Yee, W.-X., Abu Bakar, F., Lee, B., Kam, Y.-W., Lum, F.-M., Tan, J.J.L., Lim, V.W.X., Watthanaworawit, W., Ling, C., Nosten, F., Renia, L., Leo, Y.-S., Ng, L.F.P.
Published 2021

Plasmodium co-infection protects against chikungunya virus-induced pathologies

by Teo, T.-H, Lum, F.-M, Ghaffar, K, Chan, Y.-H, Amrun, S.N, Tan, J.J.L, Lee, C.Y.P, Chua, T.-K, Carissimo, G, Lee, W.W.L, Claser, C, Rajarethinam, R, Rénia, L, Ng, L.F.P
Published 2020

Longitudinal [18F]FB-IL-2 PET Imaging to Assess the Immunopathogenicity of O'nyong-nyong Virus Infection

by Chan, Y.-H., Teo, T.-H., Torres-Ruesta, A, Hartimath, S.V., Chee, R.S.-L., Khanapur, S., Yong, F.F., Ramasamy, B., Cheng, P., Rajarethinam, R., Robins, E.G., Goggi, J.L., Lum, F.-M., Carissimo, G., Rénia, L., Ng, L.F.P.
Published 2021

Zika virus infection preferentially counterbalances human peripheral monocyte and/or NK cell activity

by Lum, F.-M, Lee, D, Chua, T.-K, Tan, J.J, Lee, C.Y.P, Liu, X, Fang, Y, Lee, B, Yee, W.-X, Rickett, N.Y, Chia, P.-Y, Lim, V, Leo, Y.-S, Matthews, D.A, Hiscox, J.A, Nga, L.F.P
Published 2020

Mutating chikungunya virus non-structural protein produces potent live-attenuated vaccine candidate

by Chan, Y.-H., Teo, T.-H., Utt, A., Tan, J.J.L., Amrun, S.N., Abu Bakar, F., Yee, W.-X., Becht, E., Lee, C.Y.-P., Lee, B., Rajarethinam, R., Newell, E., Merits, A., Carissimo, G., Lum, F.-M., Ng, L.F.P.
Published 2021

Multimodal assessments of Zika virus immune pathophysiological responses in marmosets

by Lum, F.-M, Zhang, W, Lim, K.-C, Malleret, B, Teo, T.-H, Koh, J.-J, Lee, K.J, Chua, T.-K, Kam, Y.-W, Yee, W.-X, Huen, I, Tan, J.J.L, Amrun, S.N, Prakash KN, B, Cozzone, P.J, Renia, L, Lee, P.T.H, Ng, L.F.P
Published 2020

Loss of TLR3 aggravates CHIKV replication and pathology due to an altered virus-specific neutralizing antibody response

by Her, Z, Teng, T.-S, Tan, J.J.L, Teo, T.-H, Kam, Y.-W, Lum, F.-M, Lee, W.W.L, Gabriel, C, Melchiotti, R, Andiappan, A.K, Lulla, V, Lulla, A, Win, M.K, Chow, A, Biswas, S.K, Leo, Y.-S, Lecuit, M, Merits, A, Rénia, L, Ng, L.F.P
Published 2020

Cross-reactive dengue human monoclonal antibody prevents severe pathologies and death from Zika virus infections

by Kam, Y.-W, Lee, C.Y.-P, Teo, T.-H, Howland, S.W, Amrun, S.N, Lum, F.-M, See, P, Kng, N.Q.-R, Huber, R.G, Xu, M.-H, Tan, H.-L, Choo, A, Maurer-Stroh, S, Ginhoux, F, Fink, K, Wang, C.-I, Ng, L.F, R‚nia, L
Published 2020

Early neutralizing IgG response to Chikungunya virus in infected patients targets a dominant linear epitope on the E2 glycoprotein

by Kam, Y.W., Lum, F.M., Teo, T.H., Lee, W.W.L., Simarmata, D., Harjanto, S., Chua, C.L., Chan, Y.F., Wee, J.K., Chow, A., Lin, R.T.P., Leo, Y.S., Le Grand, R., Sam, I.C., Tong, J.C., Roques, P., Wiesmuller, K.H., Renia, L., Rotzschke, O., Ng, L.F.P.
Published 2012

Immunological observations and transcriptomic analysis of trimester-specific full-term placentas from three Zika virus-infected women

by Lum, F.-M., Narang, V., Hue, S., Chen, J., McGovern, N., Rajarethinam, R., Tan, J.J.L., Amrun, S.N., Chan, Y.-H., Lee, C.Y.P., Chua, T.-K., Yee, W.-X., Yeo, N.K.W., Tan, T.-C., Liu, X., Haldenby, S., Leo, Y.-S., Ginhoux, F., Chan, J.K.Y., Hiscox, J., Chong, C.-Y., Ng, L.F.P.
Published 2021