Co-infection with Chikungunya virus alters trafficking of pathogenic CD8+ T cells into the brain and prevents Plasmodium-induced neuropathology

• Main Authors: Teo, T.-H, Howland, S.W, Claser, C, Gun, S.Y, Poh, C.M, Lee, W.W.L, Lum, F.-M, Ng, L.F.P, Rénia, L
• Other Authors: DEPT OF BIOCHEMISTRY
• Format: Article
• Published: 2020
• Subjects: chemokine receptor CXCR3; CXCL9 chemokine; gamma interferon; gamma interferon inducible protein 10; leukosialin; animal experiment; animal model; animal tissue; Article; blood brain barrier; CD8+ T lymphocyte; cerebral malaria; Chikungunya virus; controlled study; cross presentation; cytokine production; female; infection sensitivity; lymphocyte migration; male; mixed infection; mortality rate; mouse; neuropathology; nonhuman; Plasmodium; Plasmodium berghei infection; priority journal; protein expression; animal; brain; C57BL mouse; cell motion; chikungunya; parasitology; pathology; physiology; Plasmodium berghei; protection; virology; Animals; Brain; CD8-Positive T-Lymphocytes; Cell Movement; Chikungunya Fever; Coinfection; Female; Malaria, Cerebral; Male; Mice; Mice, Inbred C57BL; Neuropathology; Protective Factors
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/178125
• Institution: National University of Singapore

10.15252/emmm.201707885