Winner's Curse Correction and Variable Thresholding Improve Performance of Polygenic Risk Modeling Based on Genome-Wide Association Study Summary-Level Data

by Shi J., Park J.-H., Duan J., Berndt S.T., Moy W., Yu K., Song L., Wheeler W., Hua X., Silverman D., Garcia-Closas M., Hsiung C.A., Figueroa J.D., Cortessis V.K., Malats N., Karagas M.R., Vineis P., Chang I.-S., Lin D., Zhou B., Seow A., Matsuo K., Hong Y.-C., Caporaso N.E., Wolpin B., Jacobs E., Petersen G.M., Klein A.P., Li D., Risch H., Sanders A.R., Hsu L., Schoen R.E., Brenner H., MGS (Molecular Genetics of Schizophrenia) GWAS Consortium, GECCO (The Genetics and Epidemiology of Colorectal Cancer Consortium), The GAME-ON/TRICL (Transdisciplinary Research in Cancer of the Lung) GWAS Consortium, PRACTICAL (PRostate cancer AssoCiation group To Investigate Cancer Associated aLterations) Consortium, PanScan Consortium, The GAME-ON/ELLIPSE Consortium, Stolzenberg-Solomon R., Gejman P., Lan Q., Rothman N., Amundadottir L.T., Landi M.T., Levinson D.F., Chanock S.J., Chatterjee N.
Published 2018