Winner's Curse Correction and Variable Thresholding Improve Performance of Polygenic Risk Modeling Based on Genome-Wide Association Study Summary-Level Data

• المؤلفون الرئيسيون: Shi J., Park J.-H., Duan J., Berndt S.T., Moy W., Yu K., Song L., Wheeler W., Hua X., Silverman D., Garcia-Closas M., Hsiung C.A., Figueroa J.D., Cortessis V.K., Malats N., Karagas M.R., Vineis P., Chang I.-S., Lin D., Zhou B., Seow A., Matsuo K., Hong Y.-C., Caporaso N.E., Wolpin B., Jacobs E., Petersen G.M., Klein A.P., Li D., Risch H., Sanders A.R., Hsu L., Schoen R.E., Brenner H., MGS (Molecular Genetics of Schizophrenia) GWAS Consortium, GECCO (The Genetics and Epidemiology of Colorectal Cancer Consortium), The GAME-ON/TRICL (Transdisciplinary Research in Cancer of the Lung) GWAS Consortium, PRACTICAL (PRostate cancer AssoCiation group To Investigate Cancer Associated aLterations) Consortium, PanScan Consortium, The GAME-ON/ELLIPSE Consortium, Stolzenberg-Solomon R., Gejman P., Lan Q., Rothman N., Amundadottir L.T., Landi M.T., Levinson D.F., Chanock S.J., Chatterjee N.
• مؤلفون آخرون: SAW SWEE HOCK SCHOOL OF PUBLIC HEALTH
• التنسيق: مقال
• منشور في: Public Library of Science (PLoS) 2018
• الوصول للمادة أونلاين: http://scholarbank.nus.edu.sg/handle/10635/142688
• المؤسسة: National University of Singapore

10.1371/journal.pgen.1006493