Winner's Curse Correction and Variable Thresholding Improve Performance of Polygenic Risk Modeling Based on Genome-Wide Association Study Summary-Level Data

Winner's Curse Correction and Variable Thresholding Improve Performance of Polygenic Risk Modeling Based on Genome-Wide Association Study Summary-Level Data

10.1371/journal.pgen.1006493

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Main Authors: Shi J., Park J.-H., Duan J., Berndt S.T., Moy W., Yu K., Song L., Wheeler W., Hua X., Silverman D., Garcia-Closas M., Hsiung C.A., Figueroa J.D., Cortessis V.K., Malats N., Karagas M.R., Vineis P., Chang I.-S., Lin D., Zhou B., Seow A., Matsuo K., Hong Y.-C., Caporaso N.E., Wolpin B., Jacobs E., Petersen G.M., Klein A.P., Li D., Risch H., Sanders A.R., Hsu L., Schoen R.E., Brenner H., MGS (Molecular Genetics of Schizophrenia) GWAS Consortium, GECCO (The Genetics and Epidemiology of Colorectal Cancer Consortium), The GAME-ON/TRICL (Transdisciplinary Research in Cancer of the Lung) GWAS Consortium, PRACTICAL (PRostate cancer AssoCiation group To Investigate Cancer Associated aLterations) Consortium, PanScan Consortium, The GAME-ON/ELLIPSE Consortium, Stolzenberg-Solomon R., Gejman P., Lan Q., Rothman N., Amundadottir L.T., Landi M.T., Levinson D.F., Chanock S.J., Chatterjee N.
Other Authors: SAW SWEE HOCK SCHOOL OF PUBLIC HEALTH
Format: Article
Published: Public Library of Science (PLoS) 2018
Online Access:http://scholarbank.nus.edu.sg/handle/10635/142688
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spelling sg-nus-scholar.10635-1426882024-11-11T23:47:38Z Winner's Curse Correction and Variable Thresholding Improve Performance of Polygenic Risk Modeling Based on Genome-Wide Association Study Summary-Level Data Shi J. Park J.-H. Duan J. Berndt S.T. Moy W. Yu K. Song L. Wheeler W. Hua X. Silverman D. Garcia-Closas M. Hsiung C.A. Figueroa J.D. Cortessis V.K. Malats N. Karagas M.R. Vineis P. Chang I.-S. Lin D. Zhou B. Seow A. Matsuo K. Hong Y.-C. Caporaso N.E. Wolpin B. Jacobs E. Petersen G.M. Klein A.P. Li D. Risch H. Sanders A.R. Hsu L. Schoen R.E. Brenner H. MGS (Molecular Genetics of Schizophrenia) GWAS Consortium GECCO (The Genetics and Epidemiology of Colorectal Cancer Consortium) The GAME-ON/TRICL (Transdisciplinary Research in Cancer of the Lung) GWAS Consortium PRACTICAL (PRostate cancer AssoCiation group To Investigate Cancer Associated aLterations) Consortium PanScan Consortium The GAME-ON/ELLIPSE Consortium Stolzenberg-Solomon R. Gejman P. Lan Q. Rothman N. Amundadottir L.T. Landi M.T. Levinson D.F. Chanock S.J. Chatterjee N. SAW SWEE HOCK SCHOOL OF PUBLIC HEALTH 10.1371/journal.pgen.1006493 PLoS Genetics 12 12 e1006493 2018-05-30T07:11:37Z 2018-05-30T07:11:37Z 2016 Article Shi J., Park J.-H., Duan J., Berndt S.T., Moy W., Yu K., Song L., Wheeler W., Hua X., Silverman D., Garcia-Closas M., Hsiung C.A., Figueroa J.D., Cortessis V.K., Malats N., Karagas M.R., Vineis P., Chang I.-S., Lin D., Zhou B., Seow A., Matsuo K., Hong Y.-C., Caporaso N.E., Wolpin B., Jacobs E., Petersen G.M., Klein A.P., Li D., Risch H., Sanders A.R., Hsu L., Schoen R.E., Brenner H., MGS (Molecular Genetics of Schizophrenia) GWAS Consortium, GECCO (The Genetics and Epidemiology of Colorectal Cancer Consortium), The GAME-ON/TRICL (Transdisciplinary Research in Cancer of the Lung) GWAS Consortium, PRACTICAL (PRostate cancer AssoCiation group To Investigate Cancer Associated aLterations) Consortium, PanScan Consortium, The GAME-ON/ELLIPSE Consortium, Stolzenberg-Solomon R., Gejman P., Lan Q., Rothman N., Amundadottir L.T., Landi M.T., Levinson D.F., Chanock S.J., Chatterjee N. (2016). Winner's Curse Correction and Variable Thresholding Improve Performance of Polygenic Risk Modeling Based on Genome-Wide Association Study Summary-Level Data. PLoS Genetics 12 (12) : e1006493. ScholarBank@NUS Repository. https://doi.org/10.1371/journal.pgen.1006493 15537390 http://scholarbank.nus.edu.sg/handle/10635/142688 000392138700036 Public Library of Science (PLoS) Scopus
institution National University of Singapore
building NUS Library
continent Asia
country Singapore
Singapore
content_provider NUS Library
collection ScholarBank@NUS
description 10.1371/journal.pgen.1006493
author2 SAW SWEE HOCK SCHOOL OF PUBLIC HEALTH
author_facet SAW SWEE HOCK SCHOOL OF PUBLIC HEALTH
Shi J.
Park J.-H.
Duan J.
Berndt S.T.
Moy W.
Yu K.
Song L.
Wheeler W.
Hua X.
Silverman D.
Garcia-Closas M.
Hsiung C.A.
Figueroa J.D.
Cortessis V.K.
Malats N.
Karagas M.R.
Vineis P.
Chang I.-S.
Lin D.
Zhou B.
Seow A.
Matsuo K.
Hong Y.-C.
Caporaso N.E.
Wolpin B.
Jacobs E.
Petersen G.M.
Klein A.P.
Li D.
Risch H.
Sanders A.R.
Hsu L.
Schoen R.E.
Brenner H.
MGS (Molecular Genetics of Schizophrenia) GWAS Consortium
GECCO (The Genetics and Epidemiology of Colorectal Cancer Consortium)
The GAME-ON/TRICL (Transdisciplinary Research in Cancer of the Lung) GWAS Consortium
PRACTICAL (PRostate cancer AssoCiation group To Investigate Cancer Associated aLterations) Consortium
PanScan Consortium
The GAME-ON/ELLIPSE Consortium
Stolzenberg-Solomon R.
Gejman P.
Lan Q.
Rothman N.
Amundadottir L.T.
Landi M.T.
Levinson D.F.
Chanock S.J.
Chatterjee N.
format Article
author Shi J.
Park J.-H.
Duan J.
Berndt S.T.
Moy W.
Yu K.
Song L.
Wheeler W.
Hua X.
Silverman D.
Garcia-Closas M.
Hsiung C.A.
Figueroa J.D.
Cortessis V.K.
Malats N.
Karagas M.R.
Vineis P.
Chang I.-S.
Lin D.
Zhou B.
Seow A.
Matsuo K.
Hong Y.-C.
Caporaso N.E.
Wolpin B.
Jacobs E.
Petersen G.M.
Klein A.P.
Li D.
Risch H.
Sanders A.R.
Hsu L.
Schoen R.E.
Brenner H.
MGS (Molecular Genetics of Schizophrenia) GWAS Consortium
GECCO (The Genetics and Epidemiology of Colorectal Cancer Consortium)
The GAME-ON/TRICL (Transdisciplinary Research in Cancer of the Lung) GWAS Consortium
PRACTICAL (PRostate cancer AssoCiation group To Investigate Cancer Associated aLterations) Consortium
PanScan Consortium
The GAME-ON/ELLIPSE Consortium
Stolzenberg-Solomon R.
Gejman P.
Lan Q.
Rothman N.
Amundadottir L.T.
Landi M.T.
Levinson D.F.
Chanock S.J.
Chatterjee N.
spellingShingle Shi J.
Park J.-H.
Duan J.
Berndt S.T.
Moy W.
Yu K.
Song L.
Wheeler W.
Hua X.
Silverman D.
Garcia-Closas M.
Hsiung C.A.
Figueroa J.D.
Cortessis V.K.
Malats N.
Karagas M.R.
Vineis P.
Chang I.-S.
Lin D.
Zhou B.
Seow A.
Matsuo K.
Hong Y.-C.
Caporaso N.E.
Wolpin B.
Jacobs E.
Petersen G.M.
Klein A.P.
Li D.
Risch H.
Sanders A.R.
Hsu L.
Schoen R.E.
Brenner H.
MGS (Molecular Genetics of Schizophrenia) GWAS Consortium
GECCO (The Genetics and Epidemiology of Colorectal Cancer Consortium)
The GAME-ON/TRICL (Transdisciplinary Research in Cancer of the Lung) GWAS Consortium
PRACTICAL (PRostate cancer AssoCiation group To Investigate Cancer Associated aLterations) Consortium
PanScan Consortium
The GAME-ON/ELLIPSE Consortium
Stolzenberg-Solomon R.
Gejman P.
Lan Q.
Rothman N.
Amundadottir L.T.
Landi M.T.
Levinson D.F.
Chanock S.J.
Chatterjee N.
Winner's Curse Correction and Variable Thresholding Improve Performance of Polygenic Risk Modeling Based on Genome-Wide Association Study Summary-Level Data
author_sort Shi J.
title Winner's Curse Correction and Variable Thresholding Improve Performance of Polygenic Risk Modeling Based on Genome-Wide Association Study Summary-Level Data
title_short Winner's Curse Correction and Variable Thresholding Improve Performance of Polygenic Risk Modeling Based on Genome-Wide Association Study Summary-Level Data
title_full Winner's Curse Correction and Variable Thresholding Improve Performance of Polygenic Risk Modeling Based on Genome-Wide Association Study Summary-Level Data
title_fullStr Winner's Curse Correction and Variable Thresholding Improve Performance of Polygenic Risk Modeling Based on Genome-Wide Association Study Summary-Level Data
title_full_unstemmed Winner's Curse Correction and Variable Thresholding Improve Performance of Polygenic Risk Modeling Based on Genome-Wide Association Study Summary-Level Data
title_sort winner's curse correction and variable thresholding improve performance of polygenic risk modeling based on genome-wide association study summary-level data
publisher Public Library of Science (PLoS)
publishDate 2018
url http://scholarbank.nus.edu.sg/handle/10635/142688
_version_ 1821210725806243840

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