Hundreds of dual-stage antimalarial molecules discovered by a functional gametocyte screen

by Celia Miguel-Blanco, Irene Molina, Ana I. Bardera, Beatriz Díaz, Laura De Las Heras, Sonia Lozano, Carolina González, Janneth Rodrigues, Michael J. Delves, Andrea Ruecker, Gonzalo Colmenarejo, Sara Viera, María S. Martínez-Martínez, Esther Fernández, Jake Baum, Robert E. Sinden, Esperanza Herreros
Published 2018

Histone methyltransferase inhibitors are orally bioavailable, fast- Acting molecules with activity against different species causing malaria in humans

by Nicholas A. Malmquist, Sandeep Sundriyal, Joachim Caron, Patty Chen, Benoit Witkowski, Didier Menard, Rossarin Suwanarusk, Laurent Renia, Francois Nosten, María Belén Jiménez-Díaz, Iñigo Angulo-Barturen, María Santos Martínez, Santiago Ferrer, Laura M. Sanz, Francisco Javier Gamo, Sergio Wittlin, Sandra Duffy, Vicky M. Avery, Andrea Ruecker, Michael J. Delves, Robert E. Sinden, Matthew J. Fuchter, Artur Scherf
Published 2018

Hexahydroquinolines are antimalarial candidates with potent blood-stage and transmission-blocking activity

by Manu Vanaerschot, Leonardo Lucantoni, Tao Li, Jill M. Combrinck, Andrea Ruecker, T. R.Santha Kumar, Kelly Rubiano, Pedro E. Ferreira, Giulia Siciliano, Sonia Gulati, Philipp P. Henrich, Caroline L. Ng, James M. Murithi, Victoria C. Corey, Sandra Duffy, Ori J. Lieberman, M. Isabel Veiga, Robert E. Sinden, Pietro Alano, Michael J. Delves, Kim Lee Sim, Elizabeth A. Winzeler, Timothy J. Egan, Stephen L. Hoffman, Vicky M. Avery, David A. Fidock
Published 2018