A general strategy exploiting m5C duplex-remodelling effect for selective detection of RNA and DNA m5C methyltransferase activity in cells

by Yang, T., Low, J.J.A., Woon, E.C.Y.
Published 2021

A fluorescent methylation-switchable probe for highly sensitive analysis of FTO N6-methyladenosine demethylase activity in cells

by Cheong, A., Low, J.J.A., Lim, A., Yen, P.M., Woon, E.C.Y.
Published 2022

N 6 -Methyladenosine: A conformational marker that regulates the substrate specificity of human demethylases FTO and ALKBH5

by Zou, S, Toh, J.D.W, Wong, K.H.Q, Gao, Y.-G, Hong, W, Woon, E.C.Y
Published 2020

Linking of 2-oxoglutarate and substrate binding sites enables potent and highly selective inhibition of JmjC histone demethylases

by Woon, E.C.Y., Tumber, A., Kawamura, A., Hillringhaus, L., Ge, W., Rose, N.R., Ma, J.H.Y., Chan, M.C., Walport, L.J., Che, K.H., Ng, S.S., Marsden, B.D., Oppermann, U., McDonough, M.A., Schofield, C.J.
Published 2016

Plant growth regulator daminozide is a selective inhibitor of human KDM2/7 histone demethylases

by Rose, N.R., Woon, E.C.Y., Tumber, A., Walport, L.J., Chowdhury, R., Li, X.S., King, O.N.F., Lejeune, C., Ng, S.S., Krojer, T., Chan, M.C., Rydzik, A.M., Hopkinson, R.J., Che, K.H., Daniel, M., Strain-Damerell, C., Gileadi, C., Kochan, G., Leung, I.K.H., Dunford, J., Yeoh, K.K., Ratcliffe, P.J., Burgess-Brown, N., Von Delft, F., Muller, S., Marsden, B., Brennan, P.E., McDonough, M.A., Oppermann, U., Klose, R.J., Schofield, C.J., Kawamura, A.
Published 2016