HASE: Framework for efficient high-dimensional association analyses

by Roshchupkin, G.V, Adams, H.H.H, Vernooij, M.W, Hofman, A, Van Duijn, C.M, Ikram, M.A, Niessen, W.J
Published 2020

An IGF-I gene polymorphism modifies the risk of diabetic retinopathy

by Rietveld, I, Ikram, M.K, Vingerling, J.R, Hofman, A, Pols, H.A.P, Lamberts, S.W.J, De Jong, P.T.V.M, Van Duijn, C.M, Janssen, J.A.M.J.L
Published 2020

Heritability of the shape of subcortical brain structures in the general population

by Roshchupkin, G.V, Gutman, B.A, Vernooij, M.W, Jahanshad, N, Martin, N.G, Hofman, A, McMahon, K.L, Van Der Lee, S.J, Van Duijn, C.M, De Zubicaray, G.I, Uitterlinden, A.G, Wright, M.J, Niessen, W.J, Thompson, P.M, Ikram, M.A, Adams, H.H.H
Published 2020

Molecular genetic aetiology of general cognitive function is enriched in evolutionarily conserved regions

by Hill, W.D, Davies, G, Harris, S.E, Hagenaars, S.P, Liewald, D.C, Penke, L, Gale, C.R, Deary, I.J, Debette, S, Verbaas, C.I, Bressler, J, Schuur, M, Smith, A.V, Bis, J.C, Bennett, D.A, Ikram, M.A, Launer, L.J, Fitzpatrick, A.L, Seshadri, S, Van Duijn, C.M, Mosley, T.H
Published 2020

A genome-wide association study of optic disc parameters

by Ramdas W.D., van Koolwijk L.M.E., Ikram M.K., Jansonius N.M., de Jong P.T.V.M., Bergen A.A.B., Isaacs A., Amin N., Aulchenko Y.S., Wolfs R.C.W., Hofman A., Rivadeneira F., Oostra B.A., Uitterlinden A.G., Hysi P., Hammond C.J., Lemij H.G., Vingerling J.R., Klaver C.C.W., van Duijn C.M.
Published 2019

Genome-wide association studies in Asians confirm the involvement of ATOH7 and TGFBR3, and further identify CARD10 as a novel locus influencing optic discarea

by Khor, C.C., Ramdas, W.D., Vithana, E.N., Cornes, B.K., Sim, X., Tay, W.-T., Saw, S.-M., Lavanya, Y.Z., Wu, R., Wang, J.J., Mitchell, P., Uitterlinden, A.G., Rivadeneira, F., Teo, Y.-Y., Chia, K.-S., Seielstad, M., Hibberd, M., Vingerling, J.R., Klaver, C.C., Jansonius, N.M., Tai, E.-S., Wong, T.-Y., van Duijn, C.M., Aung, T.
Published 2014

The dopamine β-hydroxylase -1021C/T polymorphism is associated with the risk of Alzheimer's disease in the Epistasis Project

by Combarros, O, Warden, D.R, Hammond, N, Cortina-Borja, M, Belbin, O, Lehmann, M.G, Wilcock, G.K, Brown, K, Kehoe, P.G, Barber, R, Coto, E, Alvarez, V, Deloukas, P, Gwilliam, R, Heun, R, Kölsch, H, Mateo, I, Oulhaj, A, Arias-Vásquez, A, Schuur, M, Aulchenko, Y.S, Ikram, M.A, Breteler, M.M, van Duijn, C.M, Morgan, K, Smith, A.D, Lehmann, D.J
Published 2020

Associations of NINJ2 sequence variants with incident ischemic stroke in the Cohorts for Heart and Aging in Genomic Epidemiology (CHARGE) consortium

by Bis J.C., DeStefano A., Liu X., Brody J.A., Choi S.H., Verhaaren B.F.J., Debette S., Ikram M.A., Shahar E., Butler Jr. K.R., Gottesman R.F., Muzny D., Kovar C.L., Psaty B.M., Hofman A., Lumley T., Gupta M., Wolf P.A., Van Duijn C., Gibbs R.A., Mosley T.H., Longstreth Jr. W.T., Boerwinkle E., Seshadri S., Fornage M.
Published 2019

Insights into the Genetic Architecture of Early Stage Age-Related Macular Degeneration: A Genome-Wide Association Study Meta-Analysis

by Holliday, E.G., Smith, A.V., Cornes, B.K., Buitendijk, G.H.S., Jensen, R.A., Sim, X., Aspelund, T., Aung, T., Baird, P.N., Boerwinkle, E., Cheng, C.Y., van Duijn, C.M., Eiriksdottir, G., Gudnason, V., Harris, T., Hewitt, A.W., Inouye, M., Jonasson, F., Klein, B.E.K., Launer, L., Li, X., Liew, G., Lumley, T., McElduff, P., McKnight, B., Mitchell, P., Psaty, B.M., Rochtchina, E., Rotter, J.I., Scott, R.J., Tay, W., Taylor, K., Teo, Y.Y., Uitterlinden, A.G., Viswanathan, A., Xie, S., Vingerling, J.R., Klaver, C.C.W., Tai, E.S., Siscovick, D., Klein, R., Cotch, M.F., Wong, T.Y., Attia, J., Wang, J.J.
Published 2014

Genome-wide analysis of BMI in adolescents and young adults reveals additional insight into the effects of genetic loci over the life course

by Graff, M., Ngwa, J.S., Workalemahu, T., Homuth, G., Schipf, S., Teumer, A., Völzke, H., Wallaschofski, H., Abecasis, G.R., Edward, L., Francesco, C., Sanna, S., Scheet, P., Schlessinger, D., Sidore, C., Xiao, X., Wang, Z., Chanock, S.J., Jacobs, K.B., Hayes, R.B., Hu, F., Van Dam, R.M., Crout, R.J., Marazita, M.L., Shaffer, J.R., Atwood, L.D., Fox, C.S., Heard-Costa, N.L., White, C., Choh, A.C., Czerwinski, S.A., Demerath, E.W., Dyer, T.D., Towne, B., Amin, N., Oostra, B.A., Van Duijn, C.M., Zillikens, M.C., Esko, T., Nelis, M., Nikopensius, T., Metspalu, A., Strachan, D.P., Monda, K., Qi, L., North, K.E., Cupples, L.A., Gordon-Larsen, P., Berndt, S.I.
Published 2014

Genome-Wide Association Study of Retinopathy in Individuals without Diabetes

by Jensen, R.A., Sim, X., Li, X., Cotch, M.F., Ikram, M.K., Holliday, E.G., Eiriksdottir, G., Harris, T.B., Jonasson, F., Klein, B.E.K., Launer, L.J., Smith, A.V., Boerwinkle, E., Cheung, N., Hewitt, A.W., Liew, G., Mitchell, P., Wang, J.J., Attia, J., Scott, R., Glazer, N.L., Lumley, T., McKnight, B., Psaty, B.M., Taylor, K., Hofman, A., de Jong, P.T.V.M., Rivadeneira, F., Uitterlinden, A.G., Tay, W.-T., Teo, Y.Y., Seielstad, M., Liu, J., Cheng, C.-Y., Saw, S.-M., Aung, T., Ganesh, S.K., O'Donnell, C.J., Nalls, M.A., Wiggins, K.L., Kuo, J.Z., van Duijn, C.M., Gudnason, V., Klein, R., Siscovick, D.S., Rotter, J.I., Tai, E.S., Vingerling, J., Wong, T.Y.
Published 2014

Evaluation of presumably disease causing SCN1A variants in a cohort of common epilepsy syndromes

by Lal D., Reinthaler E.M., Dejanovic B., May P., Thiele H., Lehesjoki A.-E., Schwarz G., Riesch E., Ikram M.A., Van Duijn C.M., Uitterlinden A.G., Hofman A., Steinböck H., Gruber-Sedlmayr U., Neophytou B., Zara F., Hahn A., Gormley P., Becker F., Weber Y.G., Cilio M.R., Kunz W.S., Krause R., Zimprich F., Lemke J.R., Nürnberg P., Sander T., Lerche H., Neubauer B.A., Palotie A., Ruppert A.-K., Suls A., Siren A., Koeleman B., Haberlandt E., Ronen G.M., Caglayan H., Hjalgrim H., Muhle H., Schulz H., Helbig I., Altmüller J., Geldner J., Schubert J., Jabbari K., Everett K., Feucht M., Balestri M., Nothnagel M., Striano P., Møller R.S., Nabbout R., Balling R., Baulac S., Bianchi A., La Neve A., Minetti C., Giuseppe C.
Published 2019

Genome-wide meta-analysis of myopia and hyperopia provides evidence for replication of 11 loci

by Simpson C.L., Wojciechowski R., Oexle K., Murgia F., Portas L., Li X., Virginie J.M.V., Vitart V., Schache M., Mohsen Hosseini S., Hysi P.G., Raffel L.J., Cotch M.F., Chew E., Klein B.E.K., Klein R., Wong T.Y., Van Duijn C.M., Mitchell P., Saw S.M., Fossarello M., Wang J.J., Polašek O., Campbell H., Rudan I., Oostra B.A., Uitterlinden A.G., Hofman A., Rivadeneira F., Amin N., Karssen L.C., Vingerling J.R., Döring A., Bettecken T., Bencic G., Gieger C., Wichmann H.-E., Wilson J.F., Venturini C., Fleck B., Cumberland P.M., Rahi J.S., Hammond C.J., Hayward C., Wright A.F., Paterson A.D., Baird P.N., Klaver C.C.W., Rotter J.I., Pirastu M., Meitinger T., Bailey-Wilson J.E., Stambolian D.
Published 2018

Genome-wide association study of intraocular pressure identifies the GLCCI1/ICA1 region as a glaucoma susceptibility locus

by Strange, A., Bellenguez, C., Sim, X., Luben, R., Hysi, P.G., Ramdas, W.D., van Koolwijk, L.M., Freeman, C., Pirinen, M., Su, Z., Band, G., Pearson, R., Vukcevic, D., Langford, C., Deloukas, P., Hunt, S., Gray, E., Dronov, S., Potter, S.C., Tashakkori-Ghanbaria, A., Edkins, S., Bumpstead, S.J., Blackwell, J.M., Bramon, E., Brown, M.A., Casas, J.P., Corvin, A., Duncanson, A., Jankowski, J.A., Markus, H.S., Mathew, C.G., Palmer, C.N., Plomin, R., Rautanen, A., Sawcer, S.J., Trembath, R.C., Wood, N.W., Barroso, I., Leena Peltonen, L.P., Healey, P., McGuffin, P., Topouzis, F., Klaver, C.C., van Duijn, C.M., Mackey, D.A., Young, T.L., Hammond, C.J., Khaw, K.-T., Wareham, N., Wang, J.J., Wong, T.Y., Foster, P.J., Mitchell, P., Spencer, C.C., Donnelly, P., Viswanathan, A.C.
Published 2014

Common genetic determinants of intraocular pressure and primary open-angle Glaucoma

by van Koolwijk, L.M.E., Ramdas, W.D., Ikram, M.K., Jansonius, N.M., Pasutto, F., Hysi, P.G., Macgregor, S., Janssen, S.F., Hewitt, A.W., Viswanathan, A.C., ten Brink, J.B., Hosseini, S.M., Amin, N., Despriet, D.D.G., Willemse-Assink, J.J.M., Kramer, R., Rivadeneira, F., Struchalin, M., Aulchenko, Y.S., Weisschuh, N., Zenkel, M., Mardin, C.Y., Gramer, E., Welge-Lüssen, U., Montgomery, G.W., Carbonaro, F., Young, T.L., Bellenguez, C., McGuffin, P., Foster, P.J., Topouzis, F., Mitchell, P., Wang, J.J., Wong, T.Y., Czudowska, M.A., Hofman, A., Uitterlinden, A.G., Wolfs, R.C.W., de Jong, P.T.V.M., Oostra, B.A., Paterson, A.D., Mackey, D.A., Bergen, A.A.B., Reis, A., Hammond, C.J., Vingerling, J.R., Lemij, H.G., Klaver, C.C.W., van Duijn, C.M.
Published 2014

Systems genetics identifies a role for Cacna2d1 regulation in elevated intraocular pressure and glaucoma susceptibility

by Chintalapudi, S.R, Maria, D, Di Wang, X, Bailey, J.N.C, Allingham, R, Brilliant, M, Budenz, D, Fingert, J, Gaasterland, D, Gaasterland, T, Haines, J.L, Hark, L, Hauser, M, Igo, R, Hee Kang, J, Kraft, P, Lee, R, Lichter, P, Liu, Y, Moroi, S, Pasquale, L.R, Pericak-Vance, M, Realini, A, Rhee, D, Richards, J.R, Ritch, R, Schuman, J, Scott, W.K, Singh, K, Sit, A, Vollrath, D, Wollstein, G, Zack, D, Aung, T, Bonnemaijer, P, Cheng, C.-Y, Craig, J, Van Duijn, C, Gharahkhani, P, Iglesias Gonzalez, A, Hammond, C.J, Hewitt, A, Hoehn, R, Jonansson, F, Khawaja, A, Chuen Khor, C, Klaver, C.C.W, Lotery, A, MacKey, D, MacGregor, S, Pang, C, Pasutto, F, Stefansson, K, Thorleifsson, G, Thorsteinsdottir, U, Vitart, V, Vithana, E, Young, T, Zeller, T, Hysi, P.G, Wiggs, J.L, Williams, R.W, Jablonski, M.M
Published 2020

Meta-analysis of genome-wide association studies in five cohorts reveals common variants in RBFOX1, a regulator of tissue-specific splicing, associated with refractive error

by Stambolian, D., Wojciechowski, R., Oexle, K., Pirastu, M., Li, X., Raffe, L.J., Cotch, M.F., Chew, E.Y., Klein, B., Klein, R., Wong, T.Y., Simpson, C.L., Klaver, C.C.W., van Duijn, C.M., Verhoeven, V.J.M., Baird, P.N., Vitart, V., Paterson, A.D., Mitchell, P., Saw, S.M., Fossarello, M., Kazmierkiewicz, K., Murgia, F., Portas, L., Schache, M., Richardson, A., Xie, J., Wang, J.J., Rochtchina, E., Viswanathan, A.C., Hayward, C., Wright, A.F., Polašek, O., Campbell, H., Rudan, I., Oostra, B.A., Uitterlinden, A.G., Hofman, A., Rivadeneira, F., Amin, N., Karssen, L.C., Vingerling, J.R., Hosseini, S.M., Döring, A., Bettecken, T., Vatavuk, Z., Gieger, C., Wichmann, H.-E., Wilson, J.F., Fleck, B., Foster, P.J., Topouzis, F., McGuffin, P., Sim, X., Inouye, M., Holliday, E.G., Attia, J., Scott, R.J., Rotter, J.I., Meitinger, T., Bailey-Wilson, J.E.
Published 2014

Genetic Loci for Retinal Arteriolar Microcirculation

by Sim, X., Jensen, R.A., Ikram, M.K., Cotch, M.F., Li, X., MacGregor, S., Xie, J., Smith, A.V., Boerwinkle, E., Mitchell, P., Klein, R., Klein, B.E.K., Glazer, N.L., Lumley, T., McKnight, B., Psaty, B.M., de Jong, P.T.V.M., Hofman, A., Rivadeneira, F., Uitterlinden, A.G., van Duijn, C.M., Aspelund, T., Eiriksdottir, G., Harris, T.B., Jonasson, F., Launer, L.J., Attia, J., Baird, P.N., Harrap, S., Holliday, E.G., Inouye, M., Rochtchina, E., Scott, R.J., Viswanathan, A., Li, G., Smith, N.L., Wiggins, K.L., Kuo, J.Z., Taylor, K.D., Hewitt, A.W., Martin, N.G., Montgomery, G.W., Sun, C., Young, T.L., Mackey, D.A., van Zuydam, N.R., Doney, A.S.F., Palmer, C.N.A., Morris, A.D., Rotter, J.I., Tai, E.S., Gudnason, V., Vingerling, J.R., Siscovick, D.S., Wang, J.J., Wong, T.Y.
Published 2014

Four novel loci (19q13, 6q24, 12q24, and 5q14) influence the microcirculation In vivo

by Kamran Ikram, M., Xueling, S., Jensen, R.A., Cotch, M.F., Hewitt, A.W., Ikram, M.A., Wang, J.J., Klein, R., Klein, B.E.K., Breteler, M.M.B., Cheung, N., Liew, G., Mitchell, P., Uitterlinden, A.G., Rivadeneira, F., Hofman, A., de Jong, P.T.V.M., van Duijn, C.M., Kao, L., Cheng, C.-Y., Smith, A.V., Glazer, N.L., Lumley, T., McKnight, B., Psaty, B.M., Jonasson, F., Eiriksdottir, G., Aspelund, T., Harris, T.B., Launer, L.J., Taylor, K.D., Li, X., Iyengar, S.K., Xi, Q., Sivakumaran, T.A., MacKey, D.A., MacGregor, S., Martin, N.G., Young, T.L., Bis, J.C., Wiggins, K.L., Heckbert, S.R., Hammond, C.J., Andrew, T., Fahy, S., Attia, J., Holliday, E.G., Scott, R.J., Islam, F.M.A., Rotter, J.I., McAuley, A.K., Boerwinkle, E., Tai, E.S., Gudnason, V., Siscovick, D.S., Vingerling, J.R., Wong, T.Y.
Published 2014

A genome-wide association study identifies genetic loci associated with specific lobar brain volumes

by van der Lee, S.J., Knol, M.J., Chauhan, G., Satizabal, C.L., Smith, A.V., Hofer, E., Bis, J.C., Hibar, D.P., Hilal, S., van den Akker, E.B., Arfanakis, K., Bernard, M., Yanek, L.R., Amin, N., Crivello, F., Cheung, J.W., Harris, T.B., Saba, Y., Lopez, O.L., Li, S., van der Grond, J., Yu, L., Paus, T., Roshchupkin, G.V., Amouyel, P., Jahanshad, N., Taylor, K.D., Yang, Q., Mathias, R.A., Boehringer, S., Mazoyer, B., Rice, K., Cheng, C.Y., Maillard, P., van Heemst, D., Wong, T.Y., Niessen, W.J., Beiser, A.S., Beekman, M., Zhao, W., Nyquist, P.A., Chen, C., Launer, L.J., Psaty, B.M., Ikram, M.K., Vernooij, M.W., Schmidt, H., Pausova, Z., Becker, D.M., De Jager, P.L., Thompson, P.M., van Duijn, C.M., Bennett, D.A., Slagboom, P.E., Schmidt, R., Longstreth, W.T., Ikram, M.A., Seshadri, S., Debette, S., Gudnason, V., Adams, H.H.H., DeCarli, C.
Published 2021