THE INFLUENCE OF pH AND SURFACTANT IN DISSOLUTION MEDIUM ON THE DISSOLUTION OF MEFENAMIC ACID
Mefenamic acid is a weakly acidic and hydrophobic drug, therefore it has poor solubility in water, especially in acid condition. Dissolution test condition of mefenamic acid stated in USP 31 was actually irrelevant with gastrointestinal tract condition because of the high pH (pH 9,0) used. The purpo...
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| Format: | Final Project |
| Language: | Indonesia |
| Online Access: | https://digilib.itb.ac.id/gdl/view/10119 |
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| Institution: | Institut Teknologi Bandung |
| Language: | Indonesia |
| Summary: | Mefenamic acid is a weakly acidic and hydrophobic drug, therefore it has poor solubility in water, especially in acid condition. Dissolution test condition of mefenamic acid stated in USP 31 was actually irrelevant with gastrointestinal tract condition because of the high pH (pH 9,0) used. The purpose of this research was to study the influence of pH and surfactants on the dissolution rate of mefenamic acid tablets using innovator product as the reference. Mefenamic acid sample tablets used were an innovator product and some generic products to show the discriminating power of the research conditions. In vitro dissolution test of mefenamic acid tablets were done using dissolution apparatus-basket type in 900 mL of Tris buffer pH 9,0; phosphate buffer pH 6,8; and phosphate buffer pH 7,5 media with the addition of two types of surfactant (sodium lauryl sulphate and Tween 80) vary in concentration. Mefenamic acid was quantitatively analysed by UV spectrophotometry. The pH of dissolution media and the addition of surfactant have greatly affected the dissolution rate of mefenamic acid. The innovator product of mefenamic acid tablet could not meet the dissolution test condition stated in USP 31 for capsule dosage forms. |
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