FUNCTIONAL GROUP TRANSFORMATION OF CINCHONA ALKALOID: ACETYLATION AND BENZOYLATION

FUNCTIONAL GROUP TRANSFORMATION OF CINCHONA ALKALOID: ACETYLATION AND BENZOYLATION

Cinchona tree is the one of plant which consist several alkaloids component. Quinine, the major component of cinchona alkaloids, is obtained from the bark of several species of the cinchona tree. Quinine has been used as the primary treatment of malaria and, in softdrink industry as bitter taste and...

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Main Author: MARDIASTUTI, MARIA
Format: Final Project
Language:Indonesia
Subjects:
Kimia
Online Access:https://digilib.itb.ac.id/gdl/view/10847
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Institution: Institut Teknologi Bandung
Language: Indonesia
id id-itb.:10847
spelling id-itb.:108472017-09-27T11:42:34ZFUNCTIONAL GROUP TRANSFORMATION OF CINCHONA ALKALOID: ACETYLATION AND BENZOYLATION MARDIASTUTI, MARIA Kimia Indonesia Final Project INSTITUT TEKNOLOGI BANDUNG https://digilib.itb.ac.id/gdl/view/10847 Cinchona tree is the one of plant which consist several alkaloids component. Quinine, the major component of cinchona alkaloids, is obtained from the bark of several species of the cinchona tree. Quinine has been used as the primary treatment of malaria and, in softdrink industry as bitter taste and tonicum. Chemical transformation of cinchona alkaloids has been investigated since the role of quinine derivatives in modern assymmetric synthesis. In this work, acetyl quinine and benzoyl quinine have been successfully synthesized by iodinecatalyzed esterification. Both products were charactherized by UV, IR, and NMR spectroscopies. Acetyl quinine and benzoyl quinine show the activities againts murine leukemia P388 cell with IC50 = 45,0 ug/mL and IC50 = 15,5 ug/mL, respectively. <br /> text
institution Institut Teknologi Bandung
building Institut Teknologi Bandung Library
continent Asia
country Indonesia
Indonesia
content_provider Institut Teknologi Bandung
collection Digital ITB
language Indonesia
topic Kimia
spellingShingle Kimia
MARDIASTUTI, MARIA
FUNCTIONAL GROUP TRANSFORMATION OF CINCHONA ALKALOID: ACETYLATION AND BENZOYLATION
description Cinchona tree is the one of plant which consist several alkaloids component. Quinine, the major component of cinchona alkaloids, is obtained from the bark of several species of the cinchona tree. Quinine has been used as the primary treatment of malaria and, in softdrink industry as bitter taste and tonicum. Chemical transformation of cinchona alkaloids has been investigated since the role of quinine derivatives in modern assymmetric synthesis. In this work, acetyl quinine and benzoyl quinine have been successfully synthesized by iodinecatalyzed esterification. Both products were charactherized by UV, IR, and NMR spectroscopies. Acetyl quinine and benzoyl quinine show the activities againts murine leukemia P388 cell with IC50 = 45,0 ug/mL and IC50 = 15,5 ug/mL, respectively. <br />
format Final Project
author MARDIASTUTI, MARIA
author_facet MARDIASTUTI, MARIA
author_sort MARDIASTUTI, MARIA
title FUNCTIONAL GROUP TRANSFORMATION OF CINCHONA ALKALOID: ACETYLATION AND BENZOYLATION
title_short FUNCTIONAL GROUP TRANSFORMATION OF CINCHONA ALKALOID: ACETYLATION AND BENZOYLATION
title_full FUNCTIONAL GROUP TRANSFORMATION OF CINCHONA ALKALOID: ACETYLATION AND BENZOYLATION
title_fullStr FUNCTIONAL GROUP TRANSFORMATION OF CINCHONA ALKALOID: ACETYLATION AND BENZOYLATION
title_full_unstemmed FUNCTIONAL GROUP TRANSFORMATION OF CINCHONA ALKALOID: ACETYLATION AND BENZOYLATION
title_sort functional group transformation of cinchona alkaloid: acetylation and benzoylation
url https://digilib.itb.ac.id/gdl/view/10847
_version_ 1822016433922506752

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