PURIFICATION AND CHLORINATION REACTION OF C-9 HYDROXY GROUP OF QUININE ALKALOID

• Main Author: ENNY OKTARINA (NIM: 20508033), NUR
• Format: Theses
• Language: Indonesia
• Online Access: https://digilib.itb.ac.id/gdl/view/12481
• Institution: Institut Teknologi Bandung

Quinine is one of the major component of Cinchona alkaloids. Quinine has been used as antimalarial, anti-inflammatory, and drug cramps. Besides its function as a drug, quinine and other Cinchona alkaloids have important role in catalytic asymmetric synthesis. As catalyst, quinine attracts enough attention. Nowadays there are several reactions carried out to produce quinine derivatives that improve catalytic activity. Although there are three total syntheses of quinine achieved, isolation of quinine from Cinchona bark is still a major source for commercial use. Besides quinine, Cinchona alkaloid consist of another compounds. The commercial quinine contain other Cinchona alkaloids as impurities. Therefore, further purification is required if the structure of quinine will be derived. The common modifications of Cinchona alkaloids were based on substitution C-9 hydroxy group by other functional groups. Therefore, in this study have been conducted quinine purification and chlorination reactions at hydroxy group C-9. <br />