STUDY OF REFORMATSKY ADDITION REACTION TOWARDS A1-PYRROLINE-N-OXIDE

• Main Author: PEBRIANA (NIM: 20507034), RIAN
• Format: Theses
• Language: Indonesia
• Online Access: https://digilib.itb.ac.id/gdl/view/12561
• Institution: Institut Teknologi Bandung

Reformatsky reactions have been known as carbon-carbon bond forming reaction between a-haloester and aldehyde or ketone in the present of zinc. Electrophile that can be utilized in this reaction beside aldehyde or ketone, is nitrone. The synthesis of nitrones regio- and stereoselectively was still important in organic synthesis field, because the demand to these compounds for synthesizing more complex organic compound having nitrogen functional group increases. The syntheses of alkaloid compounds with Reformatsky addition reaction towards aromatic nitrone derivatives have been reported. Therefore, Reformatsky addition reaction towards cyclic aliphatic nitrone derivatives is interesting to be studied. The addition reaction is supposed to produce alkaloid precursor for synthesizing hygrine and homoproline. This research aims to study racemic and asymmetric addition reaction of Reformatsky type reagent towards A1-pyrroline N-oxide based on the analysis result of product's reaction mixture using GCMS (EI). <br />