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A non aqueous gel formulation can be used as a vehicle for the unstable substances due to hydrolysis reaction. The purpose of this study was to investigate the stability of oxytetracycline as model of unstable drug in the non aqueous gel formulation compared to aqueous gel formulation. Hydroxy propy...
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| Format: | Final Project |
| Language: | Indonesia |
| Online Access: | https://digilib.itb.ac.id/gdl/view/16175 |
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| Institution: | Institut Teknologi Bandung |
| Language: | Indonesia |
| Summary: | A non aqueous gel formulation can be used as a vehicle for the unstable substances due to hydrolysis reaction. The purpose of this study was to investigate the stability of oxytetracycline as model of unstable drug in the non aqueous gel formulation compared to aqueous gel formulation. Hydroxy propyl cellulose (HPC), propylene glycol and ethanol were use for preparation of non aqueous gel. Meanwhile aqueous gel was made using HPC, hydroxy propyl methyl cellulose (HPMC), propylene glycol, ethanol 95%, and water. Sodium metabilsufite was added to all formulation as antioxidant to prevent oxidation of oxytetracycline. The stability study were performed at 40 2 oC/75 5% RH The concentration of oxytetracyclin remaining in the sample was measured by High Performance Liquid Chromatography (HPLC). The influence of EDTA and BHA was also observed for non aqueous gel formulation. The result showed that degradation rate of oxytetracycline in non aqueous gel formulation was faster than in aqueous gel formulation indicated by colour changing from pale yellow to brown. Sodium metabisulfite and BHA that used in the formulation can not prevent the oxidation of oxytetracycline. The addition of EDTA to the preparation can reduce degradation rate of oxytetracycline. A non aqueous gel formulation used in this experiment can not enhance the stability of oxytetracycline due to hydrolysis and oxidation reaction. |
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