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2-metoxyisobutylisonitrile (MIBI) or 1-isocyano-2-methyl-2-methoxypropane is an organic <br /> <br /> <br /> <br /> <br /> <br /> <br /> ligand which can form 99m–technetium sestaMIBI complex. This complex is very useful for <br /> &...
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| Format: | Final Project |
| Language: | Indonesia |
| Online Access: | https://digilib.itb.ac.id/gdl/view/18358 |
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| Institution: | Institut Teknologi Bandung |
| Language: | Indonesia |
| Summary: | 2-metoxyisobutylisonitrile (MIBI) or 1-isocyano-2-methyl-2-methoxypropane is an organic <br />
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ligand which can form 99m–technetium sestaMIBI complex. This complex is very useful for <br />
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diagnose of infarction, ischemia, and cancer. Synthesis study of MIBI is designed with tert– <br />
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butanol as a main precursor. Dehydration of tert–butanol by concentrated sulfuric acid was <br />
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conducted in temperature 75 oC to form gasseous isobutylene. This gasseous product then <br />
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directly passed into bromine solution in methanol. This process was occured in separated <br />
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flask under room temperature and yielded 91,70 % crude product in liquid form. NMR <br />
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spectra of this crude product shows that there are 1-bromo-2-methyl-2-methoxypropane <br />
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(MIBBr) and 1–bromo–2–methylpropan–2–ol in 2:3 mixture. All products are caracterized <br />
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using 1H-NMR dan 13C-NMR spectroscopy. |
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