#TITLE_ALTERNATIVE#

• Main Author: HIDAYAT (NIM : 10510073) ; Pembimbing Dr. rer. nat. Didin Mujahidin, ECEP
• Format: Final Project
• Language: Indonesia
• Online Access: https://digilib.itb.ac.id/gdl/view/18358
• Institution: Institut Teknologi Bandung

2-metoxyisobutylisonitrile (MIBI) or 1-isocyano-2-methyl-2-methoxypropane is an organic <br /> <br /> <br /> <br /> <br /> <br /> <br /> ligand which can form 99m–technetium sestaMIBI complex. This complex is very useful for <br /> <br /> <br /> <br /> <br /> <br /> <br /> diagnose of infarction, ischemia, and cancer. Synthesis study of MIBI is designed with tert– <br /> <br /> <br /> <br /> <br /> <br /> <br /> butanol as a main precursor. Dehydration of tert–butanol by concentrated sulfuric acid was <br /> <br /> <br /> <br /> <br /> <br /> <br /> conducted in temperature 75 oC to form gasseous isobutylene. This gasseous product then <br /> <br /> <br /> <br /> <br /> <br /> <br /> directly passed into bromine solution in methanol. This process was occured in separated <br /> <br /> <br /> <br /> <br /> <br /> <br /> flask under room temperature and yielded 91,70 % crude product in liquid form. NMR <br /> <br /> <br /> <br /> <br /> <br /> <br /> spectra of this crude product shows that there are 1-bromo-2-methyl-2-methoxypropane <br /> <br /> <br /> <br /> <br /> <br /> <br /> (MIBBr) and 1–bromo–2–methylpropan–2–ol in 2:3 mixture. All products are caracterized <br /> <br /> <br /> <br /> <br /> <br /> <br /> using 1H-NMR dan 13C-NMR spectroscopy.