SINTESIS 7. KARBOKSI KROMAN .4.0N DARI GLISEROL DAN M . KRESOL SEBAGAI BAHAN PEMULA
7-Carboxy chroman-4-one, an important intermediate in the preparation of 3-benzylidene 7-carboxy chroman-4- ones which have antiinflammatory and analgesic activities, has been synthetized through new route of reaction using glycerol and m-cresol as starting materials. Glycerol was dehydrated by pota...
Saved in:
| Main Author: | |
|---|---|
| Format: | Theses |
| Language: | Indonesia |
| Online Access: | https://digilib.itb.ac.id/gdl/view/2081 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Institution: | Institut Teknologi Bandung |
| Language: | Indonesia |
| Summary: | 7-Carboxy chroman-4-one, an important intermediate in the preparation of 3-benzylidene 7-carboxy chroman-4- ones which have antiinflammatory and analgesic activities, has been synthetized through new route of reaction using glycerol and m-cresol as starting materials. Glycerol was dehydrated by potassium bisulfate to yield acrolein. Acrolein was condensed with m-cresol in benzene in the presence of sodium ethoxide as catalyst to yield 3-(3-methylphenoxy) propionaldehyde which can be cyclisized to form 7-carboxy chroman-4-one after previous oxidation. 5-Carboxy chroman-4-one was also obtained as a byproduct. |
|---|