UJI EFEK HIPOTENSIF DAUN JARAK PAGAR (JATROPHA CURCAS L, EUPHORBIACEAE) PADA TIKUS JANTAN
Aqueous extracts of the leaves of Jatropha Curcas L (Euphorbiaceae) in graded doses have been investigated in anaesthesized male adult rats of the strain Wistar. Intravenous administration was found to induce a prompt fall in arterial blood pressure of short duration, in a dose related fashion an in...
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| Format: | Theses |
| Language: | Indonesia |
| Online Access: | https://digilib.itb.ac.id/gdl/view/2123 |
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| Institution: | Institut Teknologi Bandung |
| Language: | Indonesia |
| Summary: | Aqueous extracts of the leaves of Jatropha Curcas L (Euphorbiaceae) in graded doses have been investigated in anaesthesized male adult rats of the strain Wistar. Intravenous administration was found to induce a prompt fall in arterial blood pressure of short duration, in a dose related fashion an interfal of 5 - 10 minutes was maintained betwen two successive extract administration. This hypotensive effect was not modified by atropini or propanolol pre-treatment. At the dose of 100 mg/kg body weight, Jatropha extract reduced the respon of adrenalin, noradrenalin and tyramin in doses of respectively 2, 2, 200 mcg/kg body weight (adrenergik reseptor inhibition). Interaction with yohimbin (adrenolytic) reveales that the extract prolonged the duration of its effect, suggesting that the hypotensive effect of Jatropha curcas L is likely to be mediated via c -adrenolytic mechanism. |
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