UJI EFEK HIPOTENSIF DAUN JARAK PAGAR (JATROPHA CURCAS L, EUPHORBIACEAE) PADA TIKUS JANTAN

UJI EFEK HIPOTENSIF DAUN JARAK PAGAR (JATROPHA CURCAS L, EUPHORBIACEAE) PADA TIKUS JANTAN

Aqueous extracts of the leaves of Jatropha Curcas L (Euphorbiaceae) in graded doses have been investigated in anaesthesized male adult rats of the strain Wistar. Intravenous administration was found to induce a prompt fall in arterial blood pressure of short duration, in a dose related fashion an in...

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Main Author: HARYONO, KUS
Format: Theses
Language:Indonesia
Online Access:https://digilib.itb.ac.id/gdl/view/2123
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Institution: Institut Teknologi Bandung
Language: Indonesia
id id-itb.:2123
spelling id-itb.:21232004-10-26T19:25:05ZUJI EFEK HIPOTENSIF DAUN JARAK PAGAR (JATROPHA CURCAS L, EUPHORBIACEAE) PADA TIKUS JANTAN HARYONO, KUS Indonesia Theses INSTITUT TEKNOLOGI BANDUNG https://digilib.itb.ac.id/gdl/view/2123 Aqueous extracts of the leaves of Jatropha Curcas L (Euphorbiaceae) in graded doses have been investigated in anaesthesized male adult rats of the strain Wistar. Intravenous administration was found to induce a prompt fall in arterial blood pressure of short duration, in a dose related fashion an interfal of 5 - 10 minutes was maintained betwen two successive extract administration. This hypotensive effect was not modified by atropini or propanolol pre-treatment. At the dose of 100 mg/kg body weight, Jatropha extract reduced the respon of adrenalin, noradrenalin and tyramin in doses of respectively 2, 2, 200 mcg/kg body weight (adrenergik reseptor inhibition). Interaction with yohimbin (adrenolytic) reveales that the extract prolonged the duration of its effect, suggesting that the hypotensive effect of Jatropha curcas L is likely to be mediated via c -adrenolytic mechanism. text
institution Institut Teknologi Bandung
building Institut Teknologi Bandung Library
continent Asia
country Indonesia
Indonesia
content_provider Institut Teknologi Bandung
collection Digital ITB
language Indonesia
description Aqueous extracts of the leaves of Jatropha Curcas L (Euphorbiaceae) in graded doses have been investigated in anaesthesized male adult rats of the strain Wistar. Intravenous administration was found to induce a prompt fall in arterial blood pressure of short duration, in a dose related fashion an interfal of 5 - 10 minutes was maintained betwen two successive extract administration. This hypotensive effect was not modified by atropini or propanolol pre-treatment. At the dose of 100 mg/kg body weight, Jatropha extract reduced the respon of adrenalin, noradrenalin and tyramin in doses of respectively 2, 2, 200 mcg/kg body weight (adrenergik reseptor inhibition). Interaction with yohimbin (adrenolytic) reveales that the extract prolonged the duration of its effect, suggesting that the hypotensive effect of Jatropha curcas L is likely to be mediated via c -adrenolytic mechanism.
format Theses
author HARYONO, KUS
spellingShingle HARYONO, KUS
UJI EFEK HIPOTENSIF DAUN JARAK PAGAR (JATROPHA CURCAS L, EUPHORBIACEAE) PADA TIKUS JANTAN
author_facet HARYONO, KUS
author_sort HARYONO, KUS
title UJI EFEK HIPOTENSIF DAUN JARAK PAGAR (JATROPHA CURCAS L, EUPHORBIACEAE) PADA TIKUS JANTAN
title_short UJI EFEK HIPOTENSIF DAUN JARAK PAGAR (JATROPHA CURCAS L, EUPHORBIACEAE) PADA TIKUS JANTAN
title_full UJI EFEK HIPOTENSIF DAUN JARAK PAGAR (JATROPHA CURCAS L, EUPHORBIACEAE) PADA TIKUS JANTAN
title_fullStr UJI EFEK HIPOTENSIF DAUN JARAK PAGAR (JATROPHA CURCAS L, EUPHORBIACEAE) PADA TIKUS JANTAN
title_full_unstemmed UJI EFEK HIPOTENSIF DAUN JARAK PAGAR (JATROPHA CURCAS L, EUPHORBIACEAE) PADA TIKUS JANTAN
title_sort uji efek hipotensif daun jarak pagar (jatropha curcas l, euphorbiaceae) pada tikus jantan
url https://digilib.itb.ac.id/gdl/view/2123
_version_ 1820663162745126912

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