#TITLE_ALTERNATIVE#
Wound can heal naturally through four important stages that are hemostasis, inflammation, <br /> <br /> proliferation, and remodeling. However, infection from bacteria and excess exudate fluid <br /> <br /> can impede the process. Nowadays, the development of wound dressing l...
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| Main Author: | |
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| Format: | Final Project |
| Language: | Indonesia |
| Online Access: | https://digilib.itb.ac.id/gdl/view/21663 |
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| Institution: | Institut Teknologi Bandung |
| Language: | Indonesia |
| Summary: | Wound can heal naturally through four important stages that are hemostasis, inflammation, <br />
<br />
proliferation, and remodeling. However, infection from bacteria and excess exudate fluid <br />
<br />
can impede the process. Nowadays, the development of wound dressing leads to wound <br />
<br />
dressing that can accelerate wound healing and to promote proliferation of fibroblast. In <br />
<br />
this research, nanofiber formulas were developed using a mixture of chitosan-gelatin and <br />
<br />
chitosan-polyvinyl alcohol for encapsulating propolis as the active agent. The aim of this <br />
<br />
study is to developed mixture hydrogen formula of PVA/chitosan and gelatin/chitosan with <br />
<br />
optimization of polymer concentration and flow rate that can form nanofiber using <br />
<br />
electrospinning which has uniform size, high porosity, biodegradable and strong antioxidant <br />
<br />
activity. The electrospinning production was optimized including polymer concentration and <br />
<br />
flow rate. The electrospinning process parameters selected were at 18 kV, the flow rate of 1 <br />
μL/minutes, and the nozzle to collector distance of 10 cm. The uniform nanofibers were <br />
<br />
produced using solution concentration of 20% w/v and 40% of PVA-chitosan and gelatinchitosan, <br />
<br />
respectively. The maximum propolis incorporation in those nanofibers were 40% <br />
<br />
and 15%. PVA-Chitosan formula containing 30% propolis produced the best uniform <br />
<br />
nanofibers with average fiber diameter of 80.75±17.58 nm, porosity 47.19±17.31%, water <br />
<br />
absorption capacity of 442.5±10.61%, and antioxidant activity of IC50 is 81.04±3.03 ppm <br />
<br />
analyzed using DPPH. The nanofibers formula is promising for wound healing acceleration of <br />
<br />
severe skin wound. |
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