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Diabetes mellitus is a chronic and progressive disease characterized by an increase in blood <br /> <br /> glucose levels caused by insulin deficiency in the body. Insulin levels are reduced or insufficient <br /> <br /> but the function decreases. Papaya seeds (Carica papaya...
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| Format: | Final Project |
| Language: | Indonesia |
| Online Access: | https://digilib.itb.ac.id/gdl/view/23107 |
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| Institution: | Institut Teknologi Bandung |
| Language: | Indonesia |
| Summary: | Diabetes mellitus is a chronic and progressive disease characterized by an increase in blood <br />
<br />
glucose levels caused by insulin deficiency in the body. Insulin levels are reduced or insufficient <br />
<br />
but the function decreases. Papaya seeds (Carica papaya L.) is one of the plants used empirically <br />
<br />
can lower blood glucose levels. This papaya seeds decoction has been used empirically by Pinrang <br />
<br />
Regency as a blood-lowering medication. α-amylase and α-glucosidase have been recognized as <br />
<br />
theurapeutic targets for reduction of postpradial hyperglycemia in diabetes mellitus. This research <br />
<br />
was conducted to know the potency of ethanol extract, water extract, and papaya seeds fraction <br />
<br />
as α-amylase and α-glucosidase inhibitor. Research begins with the characterization and screening <br />
<br />
of phytochemical of the crude drugs. The crude drugs is extracted by reflux method with ethanol <br />
<br />
and water solvent. The extract was characterized and then monitored chromatogram pattern <br />
<br />
using Thin Layer Chromatography (TLC). Extract that have a stronger potencial is fractionated use <br />
<br />
the Liquid-Liquid Extraction (LLE) method using n-hexane, ethyl acetate, and water as an <br />
<br />
extractant. The results showed that papaya seeds water extract has a strong activity as an α- <br />
<br />
amylase inhibitor while ethanol extract has aweak activity as an α-amylase inhibitor. Water <br />
<br />
extract and ethanol extract have weak activity as α-glucosidase inhibitor. The water fraction and <br />
<br />
ethyl acetate fraction obtained from the fractionation of water extracts exhibit similar strength of <br />
<br />
activity to the α-amylase, and both fraction have weak activity as α-glucosidase inhibitor. |
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