#TITLE_ALTERNATIVE#
Kojic acid is uses as a depigmentation agent for skin whitener which is has <br /> <br /> minimum side effects on the skin. Kojic acid is difficult to penetrate into the skin <br /> <br /> because of its hydrophilic property. The aim of this research was to encapsulate <br...
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| Main Author: | |
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| Format: | Theses |
| Language: | Indonesia |
| Online Access: | https://digilib.itb.ac.id/gdl/view/25883 |
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| Institution: | Institut Teknologi Bandung |
| Language: | Indonesia |
| Summary: | Kojic acid is uses as a depigmentation agent for skin whitener which is has <br />
<br />
minimum side effects on the skin. Kojic acid is difficult to penetrate into the skin <br />
<br />
because of its hydrophilic property. The aim of this research was to encapsulate <br />
<br />
kojic acid into the liposome structure to improve the penetration of this substance <br />
<br />
into the skin. Liposome was prepared by using thin-layer techniques with <br />
<br />
phospholipids and cholesterol. Optimization of the formula was made by using <br />
<br />
various ratios of phospholipids: cholesterol. The results showed that the best <br />
<br />
formula was found from the ratio of phospholipids: cholesterol 1:2. This liposome <br />
<br />
had a particle size of 268.3±8.21 nm, polydispersity index of 0.343±0.02 and <br />
<br />
efficiency of encapsulation of 70.50± 0.25%. Analysis using Transmission <br />
<br />
Electrons Microscope indicated that kojic acid liposome was spherical. Then <br />
<br />
several of gel bases such as NaCMC, HPMC, Viscolam, and Carbopol 940 were <br />
<br />
used to develop of Kojic acid liposome gel formula. The best gel preparation <br />
<br />
obtained from this study was a gel that using Viscolam base with a concentration <br />
<br />
of 8%. It had a pH value of 6.37 and a viscosity of 4,200 cps. This gel also had a <br />
<br />
better stability compared to other gel after being stored for 7 days at room <br />
<br />
temperature and 40 <br />
<br />
o <br />
<br />
C and humidity of 75%. There was no significant change in <br />
<br />
pH and viscosity observed from the stability study. The diffusion test of kojic acid <br />
<br />
liposome gel through snake skin membrane showed the improvement of kojic <br />
<br />
acid penetration compared to kojic acid gel without liposome system. This kojic <br />
<br />
acid liposome gel was found to be not irritating the skin. <br />
<br />
<br />
<br />
<br />
liposome system. The irritation test results indicate that the kojic acid liposome <br />
<br />
<br />
<br />
gel does not irritate the skin. <br />
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