#TITLE_ALTERNATIVE#

• Main Author: INDALIFIANY NIM: 20714308, ASTRID
• Format: Theses
• Language: Indonesia
• Online Access: https://digilib.itb.ac.id/gdl/view/25883
• Institution: Institut Teknologi Bandung

Kojic acid is uses as a depigmentation agent for skin whitener which is has <br /> <br /> minimum side effects on the skin. Kojic acid is difficult to penetrate into the skin <br /> <br /> because of its hydrophilic property. The aim of this research was to encapsulate <br /> <br /> kojic acid into the liposome structure to improve the penetration of this substance <br /> <br /> into the skin. Liposome was prepared by using thin-layer techniques with <br /> <br /> phospholipids and cholesterol. Optimization of the formula was made by using <br /> <br /> various ratios of phospholipids: cholesterol. The results showed that the best <br /> <br /> formula was found from the ratio of phospholipids: cholesterol 1:2. This liposome <br /> <br /> had a particle size of 268.3±8.21 nm, polydispersity index of 0.343±0.02 and <br /> <br /> efficiency of encapsulation of 70.50± 0.25%. Analysis using Transmission <br /> <br /> Electrons Microscope indicated that kojic acid liposome was spherical. Then <br /> <br /> several of gel bases such as NaCMC, HPMC, Viscolam, and Carbopol 940 were <br /> <br /> used to develop of Kojic acid liposome gel formula. The best gel preparation <br /> <br /> obtained from this study was a gel that using Viscolam base with a concentration <br /> <br /> of 8%. It had a pH value of 6.37 and a viscosity of 4,200 cps. This gel also had a <br /> <br /> better stability compared to other gel after being stored for 7 days at room <br /> <br /> temperature and 40 <br /> <br /> o <br /> <br /> C and humidity of 75%. There was no significant change in <br /> <br /> pH and viscosity observed from the stability study. The diffusion test of kojic acid <br /> <br /> liposome gel through snake skin membrane showed the improvement of kojic <br /> <br /> acid penetration compared to kojic acid gel without liposome system. This kojic <br /> <br /> acid liposome gel was found to be not irritating the skin. <br /> <br /> <br /> <br /> <br /> liposome system. The irritation test results indicate that the kojic acid liposome <br /> <br /> <br /> <br /> gel does not irritate the skin. <br />