#TITLE_ALTERNATIVE#

• Main Author: TRI LAKSONO NIM : 11614029 , BAMBANG
• Format: Final Project
• Language: Indonesia
• Online Access: https://digilib.itb.ac.id/gdl/view/26025
• Institution: Institut Teknologi Bandung

Hepatitis or inflammation of the liver, is an inflammation of the liver due to exposure to toxic <br /> <br /> substances. Based on the results of the Basic Health Research (RISKESDAS) in 2014, liver damage due <br /> <br /> to viral infections (acute hepatitis) has increased since 2007 and 2013, and there have been several <br /> <br /> cases of hepatitis A outbreak in several cities in Indonesia. In addition, in 2016, known cases of TB <br /> <br /> reached 360,585 patients (0.14%). Side effects of anti-tuberculosis drugs (isoniazid and rifampicin) <br /> <br /> were the cause of 58% of cases of drug-induced liver damage (DILI). This study aims to determine the <br /> <br /> effectiveness of a combination of propolis and turmeric extract in preventing liver damage due to <br /> <br /> induced isoniazid and rifampicin. Test animals in the form of male Wistar rats were weighed and <br /> <br /> divided randomly into six groups. Rats induced intraperitoneally (i.p) using Isoniazid-Rifampicin <br /> <br /> mixture for 14 days. On days 0, 7, and 14 blood was taken. Serum is separated from the blood <br /> <br /> component using micropipets to analyze alanine aminotransferase (ALT) levels, aspartate <br /> <br /> aminotransferase (AST), alkaline phosphatase, and total bilirubin. The results showed that propolis <br /> <br /> (EEP) ethanol extract 100 mg / Kg BB, turmeric ethanol extract (EEK) 100 mg / Kg BB, and a combination <br /> <br /> of 100 mg / Kg BB extract had hepatoprotective activity against the use of isoniazid and rifampicin in <br /> <br /> male wistar rats, marked with decreased levels of AST, ALT, and ALP in the blood. The extract <br /> <br /> combination has better hepatoprotective activity than silimarin and is synergistic to single extracts. <br />