ANALYSIS DEVELOPMENT METHOD OF SIMETHICONE FROM ULCER DRUGS USING FTIR SPECTROSCOPY
Simethicone is activate agent contained in ulcer drugs and works as an anti-foaming agent. In Indonesian <br /> <br /> Pharmacopoeia, the determination of simethicone is done by extracting simethicone using toluene which <br /> <br /> then measured by FTIR. This method has a...
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| Format: | Final Project |
| Language: | Indonesia |
| Online Access: | https://digilib.itb.ac.id/gdl/view/27042 |
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| Institution: | Institut Teknologi Bandung |
| Language: | Indonesia |
| Summary: | Simethicone is activate agent contained in ulcer drugs and works as an anti-foaming agent. In Indonesian <br />
<br />
Pharmacopoeia, the determination of simethicone is done by extracting simethicone using toluene which <br />
<br />
then measured by FTIR. This method has a problem that is the presence of matrix effect. In this study, <br />
<br />
paraffin is used as the internal standard in the measuring of simethicone using FTIR. The study was <br />
<br />
carried out by extracting simethicone from a solid ulcer drug samples and paraffin using diethyl ether. <br />
<br />
The organic phase was then evaporated to get the mixture of simethicone and paraffin. This mixture was <br />
<br />
measured using FTIR with KBr pellet method. Quantitative analysis was done by comparing peaks in <br />
<br />
1377 cmˉ1 and 1458 cmˉ1 wave numbers. The results show linearity in the range between 0,1–0,25 grams <br />
<br />
per 2 grams of solid sample. Based on the results above, the recommended method of analysis is 0,2 <br />
<br />
grams paraffin, simethicone in the range between 0,1–0,25 grams, solid blanko, 20 mL NaOH 1 M to <br />
<br />
separator funnel and extracted with 25 mL diethyl ether. |
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