ANALYSIS DEVELOPMENT METHOD OF SIMETHICONE FROM ULCER DRUGS USING FTIR SPECTROSCOPY

• Main Author: MUHAMMAD ARIFIN (NIM:10512069), FACHRIE
• Format: Final Project
• Language: Indonesia
• Online Access: https://digilib.itb.ac.id/gdl/view/27042
• Institution: Institut Teknologi Bandung

Simethicone is activate agent contained in ulcer drugs and works as an anti-foaming agent. In Indonesian <br /> <br /> Pharmacopoeia, the determination of simethicone is done by extracting simethicone using toluene which <br /> <br /> then measured by FTIR. This method has a problem that is the presence of matrix effect. In this study, <br /> <br /> paraffin is used as the internal standard in the measuring of simethicone using FTIR. The study was <br /> <br /> carried out by extracting simethicone from a solid ulcer drug samples and paraffin using diethyl ether. <br /> <br /> The organic phase was then evaporated to get the mixture of simethicone and paraffin. This mixture was <br /> <br /> measured using FTIR with KBr pellet method. Quantitative analysis was done by comparing peaks in <br /> <br /> 1377 cm&#713;1 and 1458 cm&#713;1 wave numbers. The results show linearity in the range between 0,1–0,25 grams <br /> <br /> per 2 grams of solid sample. Based on the results above, the recommended method of analysis is 0,2 <br /> <br /> grams paraffin, simethicone in the range between 0,1–0,25 grams, solid blanko, 20 mL NaOH 1 M to <br /> <br /> separator funnel and extracted with 25 mL diethyl ether.